Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases.
Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases.
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DOI：
10.4103/1673-5374.139474
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发表时间：
2014-08-15
影响因子：
6.1
通讯作者：
Numakawa T
中科院分区：
文献类型：
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作者：
Numakawa T
有人提出，脑源性神经营养因子（BDNF）水平/功能的改变在包括阿尔茨海默氏病在内的神经退行性疾病的病理生理学中发挥作用。 BDNF 通过刺激其高亲和力受体 TrkB 对神经存活和突触维持做出积极贡献，使得 BDNF 的上调和/或 BDNF 相关细胞内信号的激活成为治疗神经退行性疾病的有吸引力的方法。在这篇简短的评论中，我简要介绍了一些小天然化合物，例如类黄酮，它们成功地增加了 BDNF 系统的激活，并讨论了它们对神经退行性变的有益作用。
It has been suggested that altered levels/function of brain-derived neurotrophic factor (BDNF) play a role in the pathophysiology of neurodegenerative diseases including Alzheimer's disease. BDNF positively contributes to neural survival and synapse maintenance via stimulating its high affinity receptor TrkB, making upregulation of BDNF and/or activation of BDNF-related intracellular signaling an attractive approach to treating neurodegenerative diseases. In this short review, I briefly introduce small natural compounds such as flavonoids that successfully increase activation of the BDNF system and discuss their beneficial effects against neurodegeneration.