Well-Defined DNA Nanoparticles Templated by Self-Assembled M12L24 Molecular Spheres and Binding of Complementary Oligonucleotides
Well-Defined DNA Nanoparticles Templated by Self-Assembled M12L24 Molecular Spheres and Binding of Complementary Oligonucleotides
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DOI：
10.1021/ja108334g
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发表时间：
2010-11-17
影响因子：
15
通讯作者：
Fujita, Makoto
中科院分区：
文献类型：
--
作者：
Kikuchi, Takashi;Sato, Sota;Fujita, Makoto
通过12个Pd(II)离子和24个双齿配体与不同长度的寡核苷酸(n=1-3)的自组装，制备了完全单分散的DNA纳米颗粒。DNA纳米颗粒与cDNA链形成氢键，并与匹配的三聚核苷酸链(tri-A)形成不可溶的聚集体。
Perfectly monodisperse DNA nanoparticles were prepared via the self-assembly of 12 Pd(II) ions and 24 bidentate ligands functionalized with oligonucleotides of varying length (n = 1-3). The DNA nanoparticles formed hydrogen bonds with cDNA strands and an insoluble aggregate formed only with matching trimeric nucleotide strands (tri-A).