Lung Cancer Associated With Cystic Airspaces
Lung Cancer Associated With Cystic Airspaces
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DOI：
10.1097/rct.0000000000000154
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发表时间：
2015-01-01
影响因子：
1.3
通讯作者：
Zompatori, Maurizio
中科院分区：
文献类型：
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作者：
Mascalchi, Mario;Attina, Domenico;Zompatori, Maurizio
目的：本研究旨在明确肺癌囊性空腔的ct形态特征，其在连续ct扫描中的改变，以及f -18-氟-2-脱氧葡萄糖（FDG）正电子发射断层扫描摄取。方法：回顾性分析24例伴有囊性气隙的肺癌（腺癌17例，鳞状细胞癌7例，I期12例，II ~ IV期12例）的ct和F-18-FDG正电子发射断层扫描。结果：初始气隙平均直径17.6 mm（范围5 ~ 30 mm），可识别出4种形态：实性结节从囊壁向外突出（I型，n = 5）或向内突出（II型，n = 4）；囊肿壁周向增厚（III型，n = 8）；组织混杂在囊肿簇内（IV型，n = 7）。随着肿瘤的生长，空气空间大小减小9例，增大6例，不变9例。5例由III型发展为I型，5例病变完全固化。f -18-氟-2-脱氧-d -葡萄糖摄取最初在7个病变中没有到轻度，在14个病变中中度到显著。结论：无论FDG摄取情况如何，囊性空域内外的渐进性壁增厚或结节的出现/增加都应引起肺癌的怀疑。
Objective: This study aimed to define computed tomographic morphologic features of lung cancer associated with cystic airspaces, their modifications in serial computed tomographic scans, and F-18-fluoro-2-deoxy-Dglucose (FDG) positron emission tomography uptake.Methods: Computed tomographic scans and F-18-FDG positron emission tomography in 24 patients with lung cancer (17 adenocarcinomas, 7 squamous cell carcinomas, 12 stage I and 12 stage II to IV) associated with cystic airspaces were reviewed.Results: Mean diameter of airspacewas initially 17.6 mm (range, 5-30 mm), and 4 morphologic patterns were recognized: solid nodule protruding externally (type I, n = 5) or internally (type II, n = 4) from the cyst wall; circumferential thickening of the cyst wall (type III, n = 8); and tissue intermixed within clusters of cysts (type IV, n = 7). With tumor growth, air space size decreased in 9, increased in 6, and was unchanged in 9 cases. Five cases evolved from type III to type I, and 5 lesions became completely solid. F-18-fluoro-2-deoxy-D-glucose uptake was initially absent to mild in 7 and moderate to marked in 14 lesions.Conclusions: Progressive wall thickening or appearance/increase of a nodule inside or outside a cystic airspace should raise suspicion of lung cancer irrespective of FDG uptake.