Green synthesis of lignin nanoparticle in aqueous hydrotropic solution toward broadening the window for its processing and application
Green synthesis of lignin nanoparticle in aqueous hydrotropic solution toward broadening the window for its processing and application
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DOI：
10.1016/j.cej.2018.04.020
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发表时间：
2018-08-15
影响因子：
15.1
通讯作者：
Xue, Wei
中科院分区：
文献类型：
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作者：
Chen, Liheng;Zhou, Xiaoyan;Xue, Wei
为了探索一种利用可生物降解和可再生的大分子代替石油基大分子制备聚合物纳米颗粒的绿色方法，我们提出了一种新的、简便的合成木质素纳米颗粒（LNPs）的方法。LNP的流体动力学直径范围为约100 nm。80至230 nm，通过在室温下在可回收且无毒的对甲苯磺酸钠（pTsONa）水溶液中自组装形成，最低浓度高达48 g/L。我们消除了不利因素的限制加工pH值和木质素物种的优势，利用水溶化学和协同解离的截留pTsONa和固有的酚羟基和羧酸部分的LNP。由于水溶助长剂系统，各种水溶性或水不溶性药物可以溶解并包封在LNP中，包封效率高达90%。药物包封的LNPs也表现出良好的性能，具有持续的药物释放能力和生物相容性。此外，卸载的药物和游离的pTsONa可以容易地回收用于多次使用，从而实现环境可持续性。这种具有宽加工窗口的合成方法可以实现LNP的工业放大生产，并且具有广泛的潜在应用，包括但不限于生物医学领域中的通用药物/生物活性大分子负载。
To exploit a green way to produce polymer nanoparticles using biodegradable and renewable macromolecules instead of petroleum-based ones, we initiated a novel and facile method to synthesize lignin nanoparticles (LNPs). The LNPs, having a hydrodynamic diameter ranging from ca. 80 to 230 nm, were formed by self-assembly in a recyclable and non-toxic aqueous sodium p-toluenesulfonate (pTsONa) solution at room temperature, with a lowest concentration of up to 48 g/L. We eliminated the unfavorable factors of restricted processing pH and lignin species by taking advantage of the hydrotropic chemistry and the synergistic dissociation of the entrapped pTsONa and intrinsic phenolic hydroxyl and carboxylic acid moieties of the LNPs. Because of the hydrotropic system, various water-soluble or water-insoluble drugs can be dissolved and encapsulated in the LNPs with an encapsulation efficiency of up to 90%. The drug-encapsulated LNPs also showed great properties, with sustained drug-releasing capability and biocompatibility. Furthermore, the unloaded drugs and free pTsONa could be easily recycled for multiple use, thereby achieving environmental sustainability. This synthesis approach with broad processing window could realize the industrial scale-up production of LNPs and have wide potential applications, including but not limited to versatile drug/bioactive macromolecule loading in the biomedical field.