What Doesn't Kill You Makes You Stronger.
What Doesn't Kill You Makes You Stronger.
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那些杀不死你的会让你变得更强大。
DOI：
10.1016/j.devcel.2018.11.003
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发表时间：
2018
影响因子：
11.8
通讯作者：
Holzbaur,ErikaLF
中科院分区：
文献类型：
--
作者：
Stavoe,AndreaKH;Holzbaur,ErikaLF
微管切割蛋白spastin和katanin长期以来被认为是破坏微管稳定的蛋白。最近的工作表明，这些酶对微管晶格造成纳米损伤，然后通过新的GTP-微管蛋白掺入快速修复，以实现聚合物的净稳定，这一过程对神经退行性疾病有影响。
The microtubule-severing proteins spastin and katanin were long thought to destabilize microtubules. Recent work demonstrates that these enzymes inflict nano-damage on the microtubule lattice that is then rapidly repaired by new GTP-tubulin incorporation, for a net stabilization of the polymer, a process that has implications for neurodegenerative disease.