Synergistic anticancer effects of different combinations of He+O 2 plasma jet and doxorubicin on A375 melanoma cells
Synergistic anticancer effects of different combinations of He+O 2 plasma jet and doxorubicin on A375 melanoma cells
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DOI：
10.1002/ppap.202000239
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发表时间：
2021-03
影响因子：
3.5
通讯作者：
Hao Zhang;Shengduo Xu;Jishen Zhang;Bing Li;Dingxin Liu;Li Guo;Zhijie Liu;Dehui Xu
中科院分区：
文献类型：
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作者：
Hao Zhang;Shengduo Xu;Jishen Zhang;Bing Li;Dingxin Liu;Li Guo;Zhijie Liu;Dehui Xu
冷大气等离子体技术有望成为癌症辅助治疗的一种选择，因为它具有良好的抗癌效果。本文研究了He+ O2等离子体射流与临床抗癌药物阿霉素不同组合对体外培养的A375黑色素瘤细胞的作用。结果表明，等离子体射流和阿霉素的协同抗癌作用取决于它们的组合方式。尽管阿霉素不影响A375细胞中等离子体射流诱导的外源性氧化应激，但连续阿霉素治疗与后续等离子体射流治疗的协同抗癌作用显著优于同时连续阿霉素和等离子体射流治疗。有人提出，等离子体射流干预可能会创造短暂的治疗窗口，连续化疗。我们的研究结果将有助于优化治疗方法，包括抗癌药物和血浆的组合，用于未来的临床应用。
Cold atmospheric plasma technology is expected to become an option for adjuvant therapy in cancer due to its promising anticancer effect. Here, we evaluated the effects of different combinations of He+O2plasma jet and clinical anticancer drug, doxorubicin, on A375 melanoma cells in vitro. The results show that the synergistic anticancer effect of plasma jet and doxorubicin is dependent on the manner of their combination. Although doxorubicin does not affect plasma jet‐induced exogenous oxidative stress in A375 cells, the synergistic anticancer effect of continuous doxorubicin treatment with subsequent plasma jet treatment is significantly better than that of simultaneous continuous doxorubicin and plasma jet treatment. It is proposed that plasma jet interventions may create transitory therapeutic windows for continuous chemotherapy. Our results will help to optimize therapeutic approaches that include combinations of anticancer drugs and plasma for future clinical applications.