Nocardial infections in Japan from 1992 to 2001, including the first report of infection by Nocardia transvalensis
Nocardial infections in Japan from 1992 to 2001, including the first report of infection by Nocardia transvalensis
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DOI：
10.1023/b:ejep.0000024706.02325.c0
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发表时间：
2004-04-01
影响因子：
13.6
通讯作者：
Mikami, Y
中科院分区：
文献类型：
--
作者：
Kageyama, A;Yazawa, K;Mikami, Y
在1992年至2001年期间，日本诊断出303例诺卡氏菌病，并分离和鉴定了相应的病原体。对这303株菌的分类学分析表明，大多数诺卡氏菌感染是由星状诺卡氏菌群的成员引起的（72.3%）。形态鉴定结果表明，72株为N. asteroides，31株为N. cyriacigeorgica，2株为N. beijingensis、81株N. farcinica和33株N.新星。66株N.其次是巴西诺卡氏菌，其次是14株N.耳海绵状软骨感染N。transvalensis（3株）和N. pseudobrasiliensis（1株）。感染N. Transvalensis、N. cyriacigeorgica和N. beijingensis为日本首次报道。在日本，使个体易于发生诺啡肽感染的最常见因素是免疫抑制剂治疗（22.4%），包括SLE治疗（3.6%），其次是癌症（6.6%）、糖尿病（3.6%）和艾滋病（2.0%）。医院感染更常见于老年人，大多数患者年龄在61岁至80岁之间。未观察到性别之间的感染性水平存在显著差异。
In the period from 1992 to 2001, 303 cases of nocardioses were diagnosed in Japan, with the corresponding etiological agents isolated and characterized. Taxonomic analyses of these 303 strains showed that most nocardial infections were caused by members of the Nocardia asteroides group (72.3%). Speciation showed that 72 strains were N. asteroides, 31 strains were N. cyriacigeorgica, 2 strains were N. beijingensis, 81 strains were N. farcinica, and 33 strains were N. nova. Sixty-six strains of N. brasiliensis were the next most prevalent species of the total Nocardia isolates, followed by 14 strains of N. otitidiscaviarum. Infections by N. transvalensis ( 3 strains) and N. pseudobrasiliensis ( 1 strain) were also confirmed. The infections due to N. transvalensis, N. cyriacigeorgica, and N. beijingensis were the first reported in Japan. The most common factor that predisposed individuals to nocardial infection in Japan was therapy by immunosuppressive agents (22.4%), including SLE therapy (3.6%), followed by cancer (6.6%), diabetes ( 3.6%) and AIDS (2.0%). Nocardial infections occurred more commonly in the elderly, with most of the patients between the ages of 61 and 80 years of age. No significant difference regarding infectivity levels between the sexes was observed.