RAMAN-SPECTROSCOPY AND NORMAL VIBRATIONS OF PEPTIDES - CHARACTERISTIC NORMAL-MODES OF A TYPE-II BETA-TURN
RAMAN-SPECTROSCOPY AND NORMAL VIBRATIONS OF PEPTIDES - CHARACTERISTIC NORMAL-MODES OF A TYPE-II BETA-TURN
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DOI：
10.1111/j.1432-1033.1984.tb07987.x
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
LOUCHEUXLEFEBVRE, MH
中科院分区：
文献类型：
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作者：
LAGANT, P;VERGOTEN, G;LOUCHEUXLEFEBVRE, MH
记录了两性离子形式的肽 Gly-LPro-Gly-Gly 及其受保护的同系物 Z-Gly-LPro-Gly-Gly-OMe（Z = N-苄氧基羰基，OMe = 甲酯）的拉曼和红外光谱。两种肽在适当的溶剂中，即分别在二甲亚砜和氯仿中，均采用II型β-转角构象。使用修正的 Urey-Bradley 力场和特征正态振动模式对 Gly-LPro-Gly-Gly 进行正态坐标处理。它们相应的频率是从实验研究中提取的。
Raman and IR spectra were recorded for the peptide Gly-LPro-Gly-Gly in its zwitterionic form and on its protected homologue Z-Gly-LPro-Gly-Gly-OMe (Z = N-benzyloxycarbonyl and OMe = methyl ester). Both peptides adopt a type-II .beta.-turn conformation into appropriate solvents, that is in dimethylsulfoxide and chloroform, respectively. A normal coordinate treatment was performed on Gly-LPro-Gly-Gly using a modified Urey-Bradley force field and the characteristic normal modes of vibrations. Their corresponding frequencies were extracted from experimental investigations.