Powerful tools for genetic analysis come of age
Powerful tools for genetic analysis come of age
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DOI：
10.1016/s0167-7799(98)01241-4
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发表时间：
1999-03-01
影响因子：
17.3
通讯作者：
Graves, DJ
中科院分区：
文献类型：
--
作者：
Graves, DJ
包含多达数十万个不同序列的寡核苷酸或cDNA的显微阵列开始影响基因组学的发现方法和途径。可以发现基因多态性和突变，并以前所未有的速度和并行性测量基因表达。本文还讨论了这一现代技术的原理和有待进一步研究的问题。
Microscopic arrays of oligonucleotides or cDNA containing up to several hundred thousand different sequences are starting to influence methodologies and paths to discovery in genomics. Gene polymorphisms and mutations can be found and gene expression measured with unprecedented speed and parallelism. The principles of this modern technology and some of the problems awaiting further study are discussed.