Critical-Size Bone Defects: Is There a Consensus for Diagnosis and Treatment?
Critical-Size Bone Defects: Is There a Consensus for Diagnosis and Treatment?
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DOI：
10.1097/bot.0000000000001115
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发表时间：
2018-03-01
影响因子：
2.3
通讯作者：
Watson, J. Tracy
中科院分区：
文献类型：
--
作者：
Nauth, Aaron;Schemitsch, Emil;Watson, J. Tracy
存在与骨缺损相关的显著疾病负担，并且其管理具有挑战性。这些损伤具有深远的临床和经济影响，结果受到并发症和再手术率高以及功能结局差的限制。对于骨缺损的定义、可靠模型和手术治疗的最佳实践，仍然缺乏共识。本文综述了骨缺损文献的现状，重点介绍了临界骨缺损的定义、诱导膜技术的应用、生物制剂的作用以及感染性骨缺损的处理。
There is a significant burden of disease associated with bone defects, and their management is challenging. These injuries have a profound clinical and economic impact, and outcomes are limited by high rates of complication and reoperation, as well as poor functional outcomes. There remains a lack of consensus around definitions, reliable models, and best practices for the surgical management of bone defects. The current state of the literature on bone defects is reviewed here, with a focus on defining critical-size bone defect, the use of the induced membrane technique, the role of biologics, and the management of infected bone defects.