Widespread cerebral gray matter volume deficits in schizophrenia.
Widespread cerebral gray matter volume deficits in schizophrenia.
复制标题
DOI：
10.1001/archpsyc.1992.01820030027004
复制
发表时间：
1992-03
影响因子：
--
通讯作者：
R. Zipursky;K. O. Lim;E. Sullivan;Byron W. Brown;A. Pfefferbaum
中科院分区：
文献类型：
--
作者：
R. Zipursky;K. O. Lim;E. Sullivan;Byron W. Brown;A. Pfefferbaum
磁共振成像用于研究精神分裂症患者与正常对照组相比，通常观察到的大脑结构差异是否仅限于灰质或白质，以及这种异常是否可定位于限定的皮质区域。因此，22名符合精神分裂症DSM-III-R标准的患者和20名健康的社区志愿者，均为23至45岁，接受了磁共振成像扫描。7张5mm厚度的轴向磁共振成像切片被分割成脑脊液、灰质和白质区室，用于体积定量。对于健康的对照组，年龄与脑灰质而非脑白质在磁共振成像中所占的比例显著相关。在校正了年龄的正常影响后，发现精神分裂症组的灰质明显少于对照组，但白质没有差异；精神分裂症组的心室容积增加了34%。精神分裂症组在分析的所有六个皮层亚区中都有较少的灰质；这些差异在除顶叶测量外的所有测量中均具有统计学意义。这些发现对局部灰质异常的研究具有启示意义，并表明需要在精神分裂症中可能广泛存在的灰质体积缺陷的背景下表达区域脑容量测量。
Magnetic resonance imaging was used to investigate whether the structural brain differences commonly observed in patients with schizophrenia as compared with normal control subjects are specific to gray or white matter, and furthermore whether such abnormalities are localizable to circumscribed cortical regions. Accordingly, 22 patients meeting DSM-III-R criteria for schizophrenia and 20 healthy community volunteers, all 23 to 45 years old, received magnetic resonance imaging scans. Seven axial magnetic resonance imaging sections of 5-mm thickness were segmented into cerebrospinal fluid, gray matter, and white matter compartments and used for volumetric quantification. For the healthy control subjects, age correlated significantly with the percentage of all magnetic resonance imaging sections taken up by gray matter but not white matter. After correcting for the normal effect of age, the schizophrenic group was found to have significantly less gray matter than the control group but no difference in white matter; ventricular volume was 34% greater in the schizophrenic group. The schizophrenic group had less gray matter in all six cortical subregions analyzed; these differences attained statistical significance for all but the parietal measure. These findings have implications for studies of localized gray matter abnormalities and suggest that regional brain volume measurements need to be expressed in the context of possible widespread gray matter volume deficits in schizophrenia.