Convenient Synthesis of 3,3,3‐Trifluoropropanoic Acid by Hydrolytic Oxidation of 3,3,3‐Trifluoropropanal Dimethyl Acetal.
Convenient Synthesis of 3,3,3‐Trifluoropropanoic Acid by Hydrolytic Oxidation of 3,3,3‐Trifluoropropanal Dimethyl Acetal.
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DOI：
10.1002/chin.200822051
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发表时间：
2008-05
期刊：
影响因子：
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通讯作者：
T. Komata;Shinya Akiba;K. Hosoi;K. Ogura
中科院分区：
文献类型：
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作者：
T. Komata;Shinya Akiba;K. Hosoi;K. Ogura
报道了一种方便有效的制备3,3,3-三氟丙酸(1)的方法。起始原料是 1-氯-3,3,3-三氟丙烯 (2)，用甲醇和 KOH 处理，然后在酸催化下添加甲醇，可轻松转化为 3,3,3-三氟丙醛二甲基缩醛 (4)。在 FeCl3（0.025 当量）和盐酸（0.5 当量）存在下，使用 30% 过氧化氢水溶液（4.0 当量）可有效实现 4 直接转化为 1。
A convenient and efficient method for preparing 3,3,3-trifluoropropanoic acid (1) is reported. The starting material is 1-chloro-3,3,3-trifluoropropene (2) that can be easily transformed into 3,3,3-trifluoropropanal dimethyl acetal (4) on treatment with methanol and KOH followed by acid-catalyzed addition of methanol. Direct transformation of 4 into 1 was efficiently achieved with 30% aqueous hydrogen peroxide (4.0equiv.) in the presence of FeCl3(0.025equiv.) and hydrochloric acid (0.5equiv.).