Mechanics and dynamics of reconstituted cytoskeletal systems.
Mechanics and dynamics of reconstituted cytoskeletal systems.
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重构细胞骨架系统的力学和动力学。
DOI：
10.1016/j.bbamcr.2015.06.013
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Weitz DA
中科院分区：
文献类型：
--
作者：
Jensen MH;Morris EJ;Weitz DA
胞内细胞骨架是由纤维和相关结合蛋白组成的活跃的动态网络，控制着细胞的关键特性，如细胞形状和力学。由于细胞固有的复杂性，重构模型系统已被成功地用于理解控制细胞骨架过程的基本物理。在这里，我们回顾了这些重组系统的最新进展和关键方面。我们关注装配动力学和动态阻滞在确定网络力学中的重要性，并强调在包含多种生物聚合物和分子马达的更复杂的网络中，通过细胞骨架组分之间的相互作用发生的新涌现行为。
The intracellular cytoskeleton is an active dynamic network of filaments and associated binding proteins that control key cellular properties, such as cell shape and mechanics. Due to the inherent complexity of the cell, reconstituted model systems have been successfully employed to gain an understanding of the fundamental physics governing cytoskeletal processes. Here, we review recent advances and key aspects of these reconstituted systems. We focus on the importance of assembly kinetics and dynamic arrest in determining network mechanics, and highlight novel emergent behavior occurring through interactions between cytoskeletal components in more complex networks incorporating multiple biopolymers and molecular motors.