Scaling patterns of cortical folding and thickness in early human brain development in comparison with primates
Scaling patterns of cortical folding and thickness in early human brain development in comparison with primates
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DOI：
10.1093/cercor/bhad462
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发表时间：
2024-01-31
期刊：
影响因子：
3.7
通讯作者：
Holland，Maria A.
中科院分区：
文献类型：
--
作者：
Demirci，Nagehan;Holland，Maria A.
在哺乳动物中，大脑形态遵循特定的尺度模式。更大的身体有更大的大脑，其表面积超过了体积的增长，导致折叠性增加。我们最近研究了局部和全局皮质厚度的缩放规则，发现厚脑回和薄脑沟之间的皮质厚度差异也随着大脑尺寸和折叠度的增加而增加。在这里，我们使用人类连接组发育项目的受试者来研究人类的早期大脑发育，这些受试者在早产或足月出生后不久进行扫描，产生经后 29 至 43 周的大脑磁共振图像。虽然在此发育期间整体皮质厚度没有显着变化，但其分布却发生了显着变化，脑沟变薄，而脑回增厚。通过将我们的结果与我们最近对人类和 11 种非人类灵长类动物的研究进行比较，我们还将灵长类动物的进化轨迹与人类的发展进行了比较，注意到这两种趋势在体积、表面积、皮质厚度和回转指数方面是不同的。最后，我们引入全局形状指数作为回转指数的代理；虽然与回转指数密切相关，但它具有仅根据局部量计算而不生成凸包或 alpha 表面的优点。
Across mammalia, brain morphology follows specific scaling patterns. Bigger bodies have bigger brains, with surface area outpacing volume growth, resulting in increased foldedness. We have recently studied scaling rules of cortical thickness, both local and global, finding that the cortical thickness difference between thick gyri and thin sulci also increases with brain size and foldedness. Here, we investigate early brain development in humans, using subjects from the Developing Human Connectome Project, scanned shortly after pre-term or full-term birth, yielding magnetic resonance images of the brain from 29 to 43 postmenstrual weeks. While the global cortical thickness does not change significantly during this development period, its distribution does, with sulci thinning, while gyri thickening. By comparing our results with our recent work on humans and 11 non-human primate species, we also compare the trajectories of primate evolution with human development, noticing that the 2 trends are distinct for volume, surface area, cortical thickness, and gyrification index. Finally, we introduce the global shape index as a proxy for gyrification index; while correlating very strongly with gyrification index, it offers the advantage of being calculated only from local quantities without generating a convex hull or alpha surface.