Enhancement the Prediction of Postoperative Survival in Gastric Cancer by Combining the Negative Lymph Node Count with Ratio Between Positive and Examined Lymph Nodes
Enhancement the Prediction of Postoperative Survival in Gastric Cancer by Combining the Negative Lymph Node Count with Ratio Between Positive and Examined Lymph Nodes
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DOI：
10.1245/s10434-009-0863-0
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发表时间：
2010-04-01
影响因子：
3.7
通讯作者：
Liu, Xiangyu
中科院分区：
文献类型：
--
作者：
Deng, Jingyu;Liang, Han;Liu, Xiangyu
为探讨胃癌根治术后阴性淋巴结（NLN）计数对阳性淋巴结与受检淋巴结（RML）比值预测预后的影响，对456例胃癌根治术后患者进行了NLN计数。根据临床病理变量检查总生存率。NLN计数与上述预测疾病特异性总生存率的最佳变量之间的相关性进行了检查，NLN计数的截断值设计为0-9，10-14和千分之一15，5年生存率分别为4.1%，30.7%和74.8%。98例NLN计数≤ 9例患者的RML为千分之40%。这些患者的中位生存期为12个月。在88例NLN计数为10 - 14的患者中，7例中位生存期为74个月，RML为0.1-10%，52例中位生存期为47个月，RML为10.1-40%，29例中位生存期为22个月，RML> 40%。在270名NLN计数为千分之一的患者中，157名患者的中位生存期为114个月，无阳性淋巴结，62名患者的中位生存期为98个月，RML为0.1-10%，45名患者的中位生存期为40个月，RML为10.1-40%，6例中位生存期14个月，RML> 40%，NLN计数是提高胃癌RML生存率的关键因素。
The purpose of this study was to evaluate the impact of the negative lymph node (NLN) count on the prognostic prediction of the ratio between positive and examined lymph nodes (RML) in gastric cancer after curative resection.The positive and negative node counts were determined for 456 patients who underwent curative resection for gastric cancer. Overall survival was examined according to clinicopathologic variables. The correlation between the NLN count and the aforementioned best variable for prediction the disease-specific overall survival was examined.The NLN count cutoffs were designed as 0-9, 10-14, and a parts per thousand yen15, with the 5-year survival rate 4.1, 30.7, and 74.8%, respectively. RML of 98 patients who had an NLN count of nine or fewer was a parts per thousand yen40%. The median survival of these patients was 12 months. Of 88 patients who had 10 to 14 NLN count, 7 had 74-month median survival with 0.1-10% RML, 52 had 47-month median survival with 10.1-40% RML, and 29 had 22-month median survival with > 40% RML. Of 270 patients who had a parts per thousand yen15 NLN count, 157 had 114-month median survival without positive nodes, 62 had 98-month median survival with 0.1-10% RML, 45 had 40-month median survival with 10.1-40% RML, and 6 had 14-month median survival with > 40% RML.The NLN count is a key factor for improvement of survival prediction of RML in gastric cancer.