Birth weight, childhood lower respiratory tract infection, and adult lung function
Birth weight, childhood lower respiratory tract infection, and adult lung function
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DOI：
10.1136/thx.53.7.549
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发表时间：
1998-07-01
期刊：
影响因子：
10
通讯作者：
Florey, CD
中科院分区：
文献类型：
--
作者：
Shaheen, SO;Sterne, JAC;Florey, CD
背景-英国的历史队列研究发现，胎儿生长受损和儿童早期下呼吸道感染与成年晚期肺功能水平降低有关。这些关系进行了调查，在一个类似的研究在Scotland. Methods-在1985-86年的后续研究进行了1070名儿童谁出生在圣安德鲁从1921年至1935年，随后从出生到14岁的麦肯齐医学研究所。记录的信息包括出生体重和呼吸系统疾病。其中239人的肺功能进行了measured.Results-There是没有出生体重和肺功能之间的关联。两岁以前的肺炎与平均第一秒用力呼气量（FEV 1）-0.39升（95%可信区间（CI）-0.67，-0.11; p = 0.007）和平均用力肺活量（FVC）-0.60升（95% CI-0.92，-0.28; p = 0.007）的差异相关。
Background-Historical cohort studies in England have found that impaired fetal growth and lower respiratory tract infections in early childhood are associated with lower levels of lung function in late adult life. These relations are investigated in a similar study in Scotland.Methods-In 1985-86 a follow up study was carried out of 1070 children who had been born in St Andrew's from 1921 to 1935 and followed from birth to 14 years of age by the Mackenzie Institute for Medical Research. Recorded information included birth weight and respiratory illnesses. The lung function of 239 of these individuals was measured.Results-There was no association between birth weight and lung function. Pneumonia before two years of age was associated with a difference in mean forced expiratory volume in one second (FEV1) of -0.39 litres (95% confidence interval (CI) -0.67, -0.11; p = 0.007) and in mean forced vital capacity (FVC) of -0.60 litres (95% CI -0.92, -0.28; p