Staphyloxanthin: a potential target for antivirulence therapy
Staphyloxanthin: a potential target for antivirulence therapy
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DOI：
10.2147/idr.s193649
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发表时间：
2019-07
影响因子：
3.9
通讯作者：
Lijun Xue;Y. Chen;Zhiyun Yan;W. Lu;Dong Wan;Huifeng Zhu
中科院分区：
文献类型：
--
作者：
Lijun Xue;Y. Chen;Zhiyun Yan;W. Lu;Dong Wan;Huifeng Zhu
摘要金黄色葡萄球菌是引起临床感染和食物中毒的一种重要且常见的革兰氏阳性菌。由于多重耐药菌株的出现，金黄色葡萄球菌感染的治疗方案正面临挑战。寻找新的抗感染药物来控制金黄色葡萄球菌感染已成为当务之急。金黄色葡萄球菌菌株能够产生金黄色类胡萝卜素：葡萄糖素，它是一种重要的毒力因子，也是抗毒力药物设计的潜在靶点。本文综述了金黄色葡萄球菌金黄色类胡萝卜素的最新研究进展，包括葡萄糖素的生物合成、金黄色葡萄糖素的功能以及参与金黄色葡萄球菌色素产生的基因。葡萄糖素是一种新的抗病毒治疗靶点。
Abstract Staphylococcus aureus is an important and common Gram-positive bacteria which causes clinical infections and food-poisoning cases. Therapeutic schedules for treatment of S. aureus infections are facing a challenge because of the emergence of multidrug resistance strains. It is urgent to find new antiinfective drugs to control S. aureus infection. S. aureus strains are capable of producing the golden carotenoid pigment: staphyloxanthin, which acts as an important virulence factor and a potential target for antivirulence drug design. This review is aimed at presenting an updated overview of this golden carotenoid pigment of S. aureus from the biosynthesis of staphyloxanthin, its function, and the genes involved in pigment production to staphyloxanthin: a novel target for antivirulence therapy.