Evolutionary insights into DNA methylation in insects
Evolutionary insights into DNA methylation in insects
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DOI：
10.1016/j.cois.2014.04.001
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发表时间：
2014-07-01
影响因子：
5.3
通讯作者：
Goodisman, Michael A. D.
中科院分区：
文献类型：
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作者：
Glastad, Karl M.;Hunt, Brendan G.;Goodisman, Michael A. D.
表观遗传信息影响基因功能，并在发育中发挥关键作用。DNA甲基化是最普遍的表观遗传标记之一，并与昆虫的发育可塑性有关。在这里，我们综述了DNA甲基化在昆虫中的模式和功能。我们特别关注进化框架的应用如何导致对DNA甲基化作用的重要见解。我们讨论了昆虫类群间DNA甲基化进化变异的重要性，并展示了比较分析如何揭示DNA甲基化靶标的保守性。然后，我们展示了DNA甲基化在昆虫基因组中的分布如何与组蛋白修饰和变异的进化保守模式相联系。我们通过讨论昆虫中DNA甲基化的进化保守性和可变性如何提供对跨真核系统的DNA甲基化功能的洞察来得出结论。
Epigenetic information affects gene function and plays a critical role in development. DNA methylation is one of the most widespread epigenetic marks and has been linked to developmental plasticity in insects. Here, we review the patterns and functions of DNA methylation in insects. We specifically focus on how the application of an evolutionary framework has led to important insights into the role of DNA methylation. We discuss the importance of evolutionary variation in DNA methylation among insect taxa and show how comparative analyses have revealed conservation in targets of DNA methylation. We then show how the distribution of DNA methylation in insect genomes has been linked to evolutionary conserved patterns of histone modifications and variants. We conclude by discussing how the evolutionary conservation and variability of DNA methylation in insects can provide insight into the function of DNA methylation across eukaryotic systems.