Ultraviolet radiation-induced DNA damage in promoter elements inhibits gene expression.
Ultraviolet radiation-induced DNA damage in promoter elements inhibits gene expression.
复制标题
紫外线辐射诱导的启动子元件 DNA 损伤抑制基因表达。
DOI：
10.1016/s0014-5793(03)01215-8
复制
发表时间：
2003
期刊：
影响因子：
3.5
通讯作者：
Mitchell,DavidL
中科院分区：
文献类型：
--
作者：
Ghosh,Rita;Tummala,Ramakumar;Mitchell,DavidL
Repair of DNA damage in gene promoters is slower than in actively transcribed genes. Persistent damage in gene promoters though transient can have significant biological effects on regulated gene expression. In this study we investigated the effect of ultraviolet radiation on gene promoter‐associated functions when DNA damage is located within and outside transcription factor binding sites. Our results show that both cyclobutane pyrimidine dimers and (6‐4) photoproducts inhibit DNA–protein interaction, in vitro transcript production and transactivation of reporter genes. The biological significance of transient DNA damage as a mechanism in carcinogenesis is discussed.
