Cytohistologic correlation between AGUS and biopsy-detected lesions in postmenopausal women
Cytohistologic correlation between AGUS and biopsy-detected lesions in postmenopausal women
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DOI：
10.1159/000326223
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发表时间：
2000-01-01
期刊：
影响因子：
1.8
通讯作者：
Grafton, WD
中科院分区：
文献类型：
--
作者：
Obenson, K;Abreo, F;Grafton, WD
目的：为了评估50岁及以上患者的宫颈涂片发现不典型腺细胞的意义不明（AGUS）。研究设计：跨越四年的计算机记录进行了回顾性分析。30名50岁以上的患者的宫颈涂片被解释为AGUS，并在异常涂片后12个月内进行了随访活检。从活检标本的最重要的组织学诊断与宫颈涂片的亚类相关。结果：5涂片解释为AGUS，有利于反应，发现异常组织学4例：3子宫内膜息肉和1鳞状细胞癌。两个涂片被解释为AGUS，有利于异型增生，在两个病例的活检中显示鳞状上皮内病变。17例AGUS涂片显示子宫内膜细胞阳性，13例组织学异常：宫颈息肉1例，子宫内膜息肉6例，子宫内膜增生3例，子宫腺肌病3例。6例涂片解释LAS AGUS，无法分类，发现异常组织学在5例：两个宫颈息肉，子宫内膜息肉，子宫内膜癌和卵巢carcinoma.CONCLUSION：AGUS的存在下，在宫颈涂片从50岁以上的妇女是高度预测异常病变的组织学检查。尽管在组织学随访中检测到三种癌症，但检测到的最常见病变是子宫内膜息肉。
OBJECTIVE: To evaluate histologic findings in patients aged 50 and older whose cervical smears revealed atypical glandular cells of undetermined significance (AGUS).STUDY DESIGN: Computerized records spanning a four-year period were retro-spectively analyzed. Thirty patients over age 50 had cer vical smears interpreted as AGUS and had follow-up biopsies within 12 months following the abnormal smear. The most important histologic diagnosis from the biopsy specimens was correlated with the subcategory of the cervical smear.RESULTS: Five smears interpreted as AGUS, favor reactive, revealed abnormal histology in four cases: three endometrial polyps and one squamous carcinoma. Two smears interpreted as AGUS, favor dysplasia, revealed squamous intraepithelial lesions on biopsy in both cases. Seventeen smears interpreted as AGUS, favor endometrial cells, revealed abnormal histology in 13 cases: 1 docervical polyp, 6 endometrial polyps, 3 endometrial hyperplasias and 3 adenomyosis. Six patients with smears interpreted las AGUS, unclassifiable, revealed abnormal histology in five cases: two endocervical polyps, one endometrial polyp, one endometrial carcinoma and one ovarian carcinoma.CONCLUSION: The presence of AGUS in cervical smears from women over 50 was highly predictive of abnormal lesions detected by histologic examination. Although three cancers were detected on histologic follow-zip, the most common lesions detected were endometrial polyps.