Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies
Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies
复制标题
DOI：
10.1007/s10654-017-0225-3
复制
发表时间：
2017-01-01
影响因子：
13.6
通讯作者：
Yu, Jin-Tai
中科院分区：
文献类型：
--
作者：
Xu, Wei;Wang, Huifu;Yu, Jin-Tai
人们普遍认为，轻度至中度的酒精摄入量可以预防痴呆症，而过量饮酒反而会增加风险。然而，这些发现需要谨慎的解释，由于不同的方法和缺乏标准的定义，这阻碍了我们转移到预防实践。本研究的目的是调查饮酒与痴呆风险之间的潜在剂量反应关系。在电子数据库中进行系统检索，以识别相关研究。使用随机效应模型合并风险估计。纳入了11项研究，其中有73，330名参与者和4586例全因痴呆（ACD），5项研究，其中有52，715名参与者和1267例阿尔茨海默氏痴呆（AD），4项研究，其中有49，535名参与者和542例血管性痴呆。我们观察到饮酒与ACD风险之间存在非线性关系（p（非线性）< 0.05）。与痴呆风险较低相关的酒精剂量限制在最多12.5 g/天，风险在大约6 g/天时触底（RR ae 0.9）。值得注意的是，当剂量超过一定水平时，ACD风险似乎会升高（ae10%）：23杯/周或38克/天。对于酒精类型，优先推荐葡萄酒。亚组分析进一步表明，酒精对年轻人（< 60岁）对抗痴呆症的影响可能更大。适度饮酒（≥ 8 g/天）可能反而会增加风险。
It is widely believed that light-to-moderate alcohol intake may protect against dementia while excessive drinking may instead increase the risk. Nonetheless, these findings need cautious interpretations due to varying methodologies and lack of standard definition, which hindered our transferring into preventative practice. The objective of this study is to investigate the potential dose-response association between alcohol consumption and risk of dementia. A systematic search was conducted in electronic databases to identify relevant studies. Risk estimates were combined using a random-effect model. Eleven studies with 73,330 participants and 4586 cases for all-cause dementia (ACD), five studies with 52,715 participants and 1267 cases for Alzheimer's dementia (AD) and four studies with 49,535 participants and 542 cases for vascular dementia were included. We observed a nonlinear association between alcohol consumption and ACD risk (p (nonlinearity) < 0.05). The alcohol dose associated with lower risk of dementia was confined to at most 12.5 g/day, with the risk hitting bottom (RR ae 0.9) at roughly 6 g/day. Of note, the ACD risk seemed to be elevated (ae10%) when the dose surpasses certain levels: 23 drinks/week or 38 g/day. For the alcohol type, recommendation for wine is prioritized. The subgroup analysis further indicated that the effect of alcohol may be greater in younger adults (< 60 years old) with regard to fighting against dementia. Modest alcohol consumption (= 8 g/day) may instead elevate the risk.