Cross-species microRNA transmission modulates flavivirus growth in mosquitoes.
Cross-species microRNA transmission modulates flavivirus growth in mosquitoes.
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DOI：
10.1016/j.pt.2022.02.007
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发表时间：
2022-03
影响因子：
9.6
通讯作者：
Shwetha Shivaprasad;P. Sarnow
中科院分区：
文献类型：
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作者：
Shwetha Shivaprasad;P. Sarnow
蚊子可以感染多种RNA病毒。最近，Zhu等人证明了人microRNA hsa-miR-150- 5 p在蚊子的血液进食过程中获得，并通过下调糜蛋白酶AaCT-1 mRNA来保护登革病毒。这一发现表明，microRNA微载体可以作为蚊子的抗病毒方法。
Mosquitoes can be infected with a variety of RNA viruses. Recently,Zhu et al. demonstrated that human microRNA hsa-miR-150-5p is acquired by mosquitoes during blood meals and protects the Dengue virus by downregulation of chymotrypsin AaCT-1 mRNA. This finding suggests the use of microRNA antagomirs as an antiviral approach in mosquitoes.