Selective Functionalization of Hollow Nanospheres with Acid and Base Groups for Cascade Reactions
Selective Functionalization of Hollow Nanospheres with Acid and Base Groups for Cascade Reactions
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DOI：
10.1002/chem.201500532
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发表时间：
2015-05-11
影响因子：
4.3
通讯作者：
Liu, Jian
中科院分区：
文献类型：
--
作者：
Gao, Jinsuo;Zhang, Xueying;Liu, Jian
空心二氧化硅球的内表面功能化很少被报道，仍然是一个具有挑战性的课题。本文报道了一种双官能化介孔二氧化硅空心纳米球催化的脱乙酰化-亨利级联反应，其内壳为碱性胺基（-NH2），外壳为羧基（-COOH）。通过“步进接枝”和“阳离子表面活性剂辅助选择性蚀刻”策略的结合，实现了选择性功能化。与未分离的催化剂相比，选择性分离的酸碱性双催化剂在脱乙醛-亨利级联反应中具有良好的催化活性（>99%）和选择性（95%）。
The inner-surface functionalization of hollow silica spheres has rarely been reported and is still a challenging topic. Herein, we report a deacetalization-Henry cascade reaction catalyzed by dual-functionalized mesoporous silica hollow nanospheres with basic amine groups (-NH2) on the internal shell and carboxylic acid groups (-COOH) on the external shell. The selective functionalization has been realized by a combination of "step-by-step post-grafting" and "cationic surfactant-assisted selective etching" strategy. Compared to unisolated catalyst, the selectively isolated acidic and basic dual catalyst provides excellent catalytic performance for the deacetalization-Henry cascade reaction in terms of both activity (>99%) and selectivity (95 %).