Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database: an expanded data model integrating natural language text and sequence analysis programs
Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database: an expanded data model integrating natural language text and sequence analysis programs
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DOI：
10.1093/nar/29.1.296
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发表时间：
2001-01-01
影响因子：
14.9
通讯作者：
Shafer, RW
中科院分区：
文献类型：
--
作者：
Kantor, R;Machekano, R;Shafer, RW
HIV逆转录酶和蛋白酶序列数据库是一个在线关系数据库，其对人类免疫缺陷病毒（HIV）逆转录酶（RT）和蛋白酶（抗HIV治疗的分子靶标）中的进化和药物相关序列变异进行编目（hivdb.stanford.edu）。该数据库包含几乎所有已发表的HIV RT和蛋白酶序列的汇编，包括来自国际协作数据库的提交和期刊文章中发表的序列。序列与序列样本来源和分离株来源个体的抗逆转录病毒药物治疗史相关。在过去的一年中，已经增加了3500个序列，数据模型已经扩展到包括测序分离株的药物敏感性数据。数据库的内容也被整合与教学文本和两个序列分析程序的输出。
The HIV Reverse Transcriptase and Protease Sequence Database is an on-line relational database that catalogs evolutionary and drug-related sequence variation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, the molecular targets of anti-HIV therapy (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protease sequences, including submissions from international Collaboration databases and sequences published in journal articles. Sequences are linked to data about the source of the sequence sample and the antiretroviral drug treatment history of the individual from whom the isolate was obtained. During the past year 3500 sequences have been added and the data model has been expanded to include drug susceptibility data on sequenced isolates. Database content has also been integrated with didactic text and the output of two sequence analysis programs.