Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer
Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer
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DOI：
10.1245/s10434-007-9461-1
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发表时间：
2007-09-01
影响因子：
3.7
通讯作者：
Mori, Masaki
中科院分区：
文献类型：
--
作者：
Kosaka, Yoshimasa;Inoue, Hiroshi;Mori, Masaki
背景资料：TRIM 29属于TRIM蛋白家族，具有独特的结构特征，包括多个锌指基序和一个亮氨酸拉链基序。TRIM 29又称共济失调毛细血管扩张症D组互补基因，具有放射敏感性抑制功能。虽然TRIM 29已被报道为在前列腺癌和乳腺癌低表达，其在胃肠道cancer.Methods的表达还没有研究：通过使用实时逆转录-聚合酶链反应，我们分析了TRIM 29 mRNA的表达状态与各种临床病理参数在124例胃癌患者。结果：TRIM 29在胃癌组织中的表达明显高于正常组织。TRIM 29 mRNA表达的增加与组织学分级、肿瘤大小、肿瘤浸润范围和淋巴结转移等参数显著相关。在TRIM 29高表达组中，它是淋巴结转移的独立预测因子。结论：TRIM 29表达可作为判断胃癌淋巴结转移的一个良好指标。
Background: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied.Methods: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted.Results: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression.Conclusions: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.