Hamartomatous adenoma of the nonpigmented ciliary epithelium arising in iris-ciliary body coloboma. Light and electron microscopic observations.
Hamartomatous adenoma of the nonpigmented ciliary epithelium arising in iris-ciliary body coloboma. Light and electron microscopic observations.
复制标题
虹膜睫状体缺损中出现的非色素性睫状上皮错构瘤性腺瘤。
DOI：
10.1016/s0161-6420(83)34351-7
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发表时间：
1983
期刊：
影响因子：
13.7
通讯作者：
D. Robertson
中科院分区：
文献类型：
--
作者：
J. Patrinely;R. L. Font;R. Campbell;D. Robertson
一个2岁半的男孩在典型的虹膜-睫状体结肠的位置有一个缓慢扩大的肿块2年。经虹膜环切除术部分切除肿块。光镜下，肿瘤细胞被包埋在富含透明质酸酶敏感的粘多糖的粘液基质中。电镜下肿瘤可见明暗相间的细胞，有交错的细胞膜、桥粒、间隙连接、多层基底膜和大量类似玻璃体原纤维的细胞外胶原原纤维。我们认为该肿瘤是一种非色素纤毛上皮的错构瘤（先天性）腺瘤，而不是传统的（获得性）腺瘤，因为它恰好发生在虹膜和纤毛体的结缔组织缺陷内。
A 2 1/2 year-old boy had a slowly enlarging mass at the site of a typical iris-ciliary body coloboma for 2 years. The mass was excised partially by iridocyclectomy. By light microscopy, the tumor cells were embedded in a rich mucoid stroma that contained abundant hyaluronidase-sensitive acid mucopolysaccharides. By electron microscopy the tumor showed light and dark cells with interdigitating cell membranes, desmosomes, gap junctions, multi-laminar basement membrane, and numerous extracellular collagen fibrils that resembled vitreous fibrils. We believe that the tumor represents a hamartomatous (congenital) adenoma of the nonpigmented ciliary epithelium rather than a conventional (acquired) adenoma, since it developed precisely within a colobomatous defect of the iris and ciliary body.