Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus.
Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus.
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DOI：
10.1001/jamapsychiatry.2013.399
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发表时间：
2013-11
期刊：
影响因子：
25.8
通讯作者：
Neumeister, Alexander
中科院分区：
文献类型：
--
作者：
Pietrzak, Robert H;Gallezot, Jean-Dominique;Ding, Yu-Shin;Henry, Shannan;Potenza, Marc N;Southwick, Steven M;Krystal, John H;Carson, Richard E;Neumeister, Alexander
动物数据表明，慢性应激与蓝斑去甲肾上腺素转运体（NET）可用性降低有关。然而，目前还不清楚这些模型是否与创伤后应激障碍（PTSD）有关，PTSD与人类去甲肾上腺素能功能障碍有关。使用正电子发射断层扫描和放射性配体[11 C]甲基reboxylate检查以下3组个体蓝斑中的体内NET可用性：健康成人（HC组），成年人暴露于创伤谁没有发展PTSD（TC组），和成年人暴露于创伤后发展为PTSD（PTSD组），并评估蓝斑NET可用性和PTSD症状的当代表型模型之间的关系。在学术和退伍军人事务部医疗中心对以下3个研究组的56名个体进行了静息条件下的横断面正电子发射断层扫描研究：HC（n = 18）、TC（n = 16）和PTSD（n = 22）。使用临床医生-管理员PTSD量表评估蓝斑NET可用性的[11 C]甲基瑞波西汀结合潜力和PTSD症状的严重程度。PTSD组的NET可用性显著低于HC组（低41%，Cohen d = 1.07）。NET可用性在TC和HC组之间（31%差异，Cohen d = 0.79）或TC和PTSD组之间（15%差异，Cohen d = 0.28）没有显著差异。在PTSD组中，蓝斑的NET可用性与焦虑唤醒（即过度警觉）症状的严重程度独立正相关（r = 0.52），但与任何其他PTSD症状群无关。这些结果表明，PTSD与蓝斑NET可用性显著降低相关，并且该脑区NET可用性更高与PTSD患者焦虑唤醒症状的严重程度增加相关。
Animal data suggest that chronic stress is associated with a reduction in norepinephrine transporter (NET) availability in the locus coeruleus. However, it is unclear whether such models are relevant to posttraumatic stress disorder (PTSD), which has been linked to noradrenergic dysfunction in humans. To use positron emission tomography and the radioligand [11C]methylreboxetine to examine in vivo NET availability in the locus coeruleus in the following 3 groups of individuals: healthy adults (HC group), adults exposed to trauma who did not develop PTSD (TC group), and adults exposed to trauma who developed PTSD (PTSD group) and to evaluate the relationship between NET availability in the locus coeruleus and a contemporary phenotypic model of PTSD symptoms. Cross-sectional positron emission tomography study under resting conditions at academic and Veterans Affairs medical centers among 56 individuals in the following 3 study groups: HC (n = 18), TC (n = 16), and PTSD (n = 22). The [11C]methylreboxetine-binding potential of NET availability in the locus coeruleus and the severity of PTSD symptoms assessed using the Clinician-Administered PTSD Scale. The PTSD group had significantly lower NET availability than the HC group (41% lower, Cohen d = 1.07). NET availability did not differ significantly between the TC and HC groups (31% difference, Cohen d = 0.79) or between the TC and PTSD groups (15% difference, Cohen d = 0.28). In the PTSD group, NET availability in the locus coeruleus was independently positively associated with the severity of anxious arousal (ie, hypervigilance) symptoms (r = 0.52) but not with any of the other PTSD symptom clusters. These results suggest that PTSD is associated with significantly reduced NET availability in the locus coeruleus and that greater NET availability in this brain region is associated with increased severity of anxious arousal symptoms in individuals with PTSD.