Estrogen receptor quantitative measures and breast cancer survival.
Estrogen receptor quantitative measures and breast cancer survival.
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DOI：
10.1007/s10549-017-4439-6
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发表时间：
2017-12
影响因子：
3.8
通讯作者：
Lomo L
中科院分区：
文献类型：
--
作者：
Hill DA;Barry M;Wiggins C;Nibbe A;Royce M;Prossnitz E;Lomo L
While the estrogen receptor (ER) is the single most widely used biomarker to evaluate breast cancer outcomes, aspects of ER marker biology remain poorly understood. We sought to determine whether quantitative measures of ER, such as protein expression and intensity, were associated with survival, or with survival disparities experienced by Hispanic women. A case-cohort study included a 15% random sample of invasive breast cancer cases diagnosed from 1997–2009 in 6 New Mexico counties and all deaths due to breast cancer-related causes. Pathology reports and tissue microarrays served as sources of ER information. Analyses were restricted to women with ≥1% ER immunohistochemical staining. Hazard ratios (HR) and 95% confidence intervals (CI) for breast cancer death were estimated using Cox proportional hazards models. Included women represented 4336 ER+ breast cancer cases and 448 deaths. Median follow-up was 93 months. ER percent expression was not associated with breast cancer survival after adjustment for standard prognostic factors (p-trend = .76). ER intensity remained a strong and independent risk factor for breast cancer survival in multivariate analyses: Women whose tumors expressed ER at intensity=2 (HR 0.6; 95% CI 0.4–1.0) or 3 (HR 0.5; 95% CI 0.2–0.9) had a reduced risk of breast cancer mortality, compared to ER intensity=1 (p-trend = .02). Neither ER protein expression nor intensity influenced Hispanic survival disparities. ER percent positive staining is not independently related to breast cancer survival after adjustment for other survival-related factors. ER intensity, in contrast, demonstrates promise for prognostic utility.
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DOI：
10.1158/1078-0432.ccr-10-1533
发表时间：
2010-12-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
O'Brien KM;Cole SR;Tse CK;Perou CM;Carey LA;Foulkes WD;Dressler LG;Geradts J;Millikan RC
通讯作者：
Millikan RC
影响因子：
5
作者：
Chung, Gina G.;Zerkowski, Maciej P.;Rimm, David L.
通讯作者：
Rimm, David L.
影响因子：
8.4
作者：
THORPE, SM;CHRISTENSEN, IJ;ROSE, C
通讯作者：
ROSE, C
影响因子：
168.9
作者：
Davies, C.;Godwin, J.;Gray, R.;Clarke, M.;Darby, S.;McGale, P.;Wang, Y. C.;Peto, R.;Pan, H. C.;Cutter, D.;Taylor, C.;Ingle, J.
通讯作者：
Ingle, J.
影响因子：
4.8
作者：
Fowler, AM;Solodin, N;Alarid, ET
通讯作者：
Alarid, ET