RELATIONSHIPS BETWEEN LYMPHATIC PUMP FLOW AND TOTAL LYMPH-FLOW IN THE SMALL-INTESTINE
RELATIONSHIPS BETWEEN LYMPHATIC PUMP FLOW AND TOTAL LYMPH-FLOW IN THE SMALL-INTESTINE
复制标题
DOI：
10.1152/ajpheart.1991.261.6.h1970
复制
发表时间：
1991-12-01
影响因子：
--
通讯作者：
BENOIT, JN
中科院分区：
文献类型：
--
作者：
BENOIT, JN
在体内研究了集合淋巴管对淋巴形成急性升高的反应。制备33只大鼠肠系膜用于活体显微镜研究，并监测淋巴推进指标（收缩频率、每搏输出量和射血分数）。在 14 只大鼠中，通过对主肠淋巴干插管来测量总淋巴流量。对照期后，通过用等渗盐水进行血液稀释来增加淋巴流量。血液稀释期间右心房压力没有显着升高。总淋巴流量增加至对照的约 25 倍。五个淋巴管（第一组）的淋巴推进力（每搏输出量和收缩频率的乘积）下降。在 22 个淋巴管中，淋巴推进力增加了对照的一到五倍（第二组）。其余六个淋巴管的淋巴推进力增加了五倍以上（第 III 组）。第一组具有最大的舒张末期直径、最高的基线收缩频率，并且不随着淋巴充盈的增加而扩张。第三组具有最小的初始舒张末期直径和最低的基线收缩频率，并且随着淋巴充盈的增加，舒张末期直径加倍。第二组的特征介于第一组和第三组之间。当淋巴流量小于对照的五倍时，第 III 组淋巴管的总淋巴流量和淋巴推进趋于一致。在水肿较多的情况下，总淋巴流量超过淋巴泵流量。第二组的特征介于第一组和第三组之间。对淋巴网络内各种大小淋巴管位置的分析表明，较小的第III组淋巴管位于更靠近肠壁的位置，而较大的第I组淋巴管更靠近肠系膜的流出处。将这些数据纳入理论分析表明，当淋巴形成速率低于对照的五倍时，淋巴泵占抵抗水肿形成的淋巴安全因素的大部分。
Response of collecting lymphatics to acute elevations in lymph formation was studied in vivo. Mesentery of 33 rats was prepared for intravital microscopic study, and indexes of lymph propulsion (contraction frequency, stroke volume, and ejection fraction) were monitored. In 14 rats, total lymph flow was measured by cannulating the main intestinal lymph trunk. After a control period, lymph flow was increased by hemodilution with isotonic saline. Right atrial pressure did not significantly increase during the hemodilution period. Total lymph flow increased to approximately 25 times control. Lymph propulsion (the product of stroke volume and contraction frequency) decreased in five lymphangions (group I). In 22 lymphangions, lymph propulsion increased one to five times control (group II). The remaining six lymphangions increased lymph propulsion by greater than five times control (group III). Group I possessed the largest end-diastolic diameter, highest baseline contraction frequency, and did not dilate as lymphatic filling increased. Group III possessed the smallest initial end-diastolic diameter and lowest baseline contraction frequency, and end-diastolic diameter doubled as lymphatic filling increased. The characteristics of group II were between those of groups I and III. Total lymph flow and lymph propulsion by group III lymphangions tended to agree when lymph flow was less than five times control. In more edematous conditions, total lymph flow exceeded lymphatic pump flow. The characteristics of group II were between those of groups I and III. Analysis of the location of various sized lymphangions within the lymphatic network indicated that the smaller group III lymphangions were located nearer the intestinal wall, and the larger group I lymphangions were nearer the outflow from the mesentery. Incorporation of these data into a theoretical analysis suggests that the lymphatic pump accounts for the majority of the lymphatic safety factor against edema formation when the rate of lymph formation is less than five times control.