Effect of cat and dog ownership on sensitization and development of asthma among preteenage children
Effect of cat and dog ownership on sensitization and development of asthma among preteenage children
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DOI：
10.1164/rccm.2201035
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发表时间：
2002-09-01
影响因子：
24.7
通讯作者：
Lundbäck, B
中科院分区：
文献类型：
--
作者：
Perzanowski, MS;Rönmark, E;Lundbäck, B
在家中暴露于大量的猫过敏原与哮喘和猫过敏之间存在反比关系。瑞典吕勒（a）、基律纳和皮特（a）的一、二年级儿童参加了一项哮喘问卷调查研究（n = 3，431），并对未来3年的发病率进行了评价。在吕勒（a）的Circle和基律纳（n = 2，149）对儿童进行了皮肤试验。哮喘发病病例的最强危险因素是1型过敏（相对危险度[RR]，4.9 [2.9-8.4]），其次是哮喘家族史（RR，2.83 [1.8-4.5]）。与猫一起生活与猫皮试阳性（1111，0.62 [0.47-0.83]）和医生诊断的哮喘发病率（1111，0.49 [0.28-0.83]）呈负相关。这种对哮喘发作的影响在有哮喘家族史的儿童中最为明显（RR，0.25 [0.08-0.80]）。证据还表明，许多在家中接触猫的儿童可以产生不包括免疫球蛋白E的免疫反应。养狗者的保护趋势较弱。传统的观点认为，不养猫可以保护那些有过敏家族史的人免受过敏和哮喘的影响，这需要重新评估。在一个社区，猫过敏与哮喘密切相关，拥有一只猫是预防流行和事件哮喘。
An inverse relationship has been proposed between exposure to high quantities of cat allergen at home and both asthma and cat allergy. First- and second-grade children from Lule (a) over circle, Kiruna, and Pite (a) over circle, Sweden participated in an asthma questionnaire study (n = 3,431) and incidence was evaluated over the next 3 years. Skin testing was performed on the children in Lule (a) over circle and Kiruna (n = 2,149). The strongest risk factor for incident cases of asthma was Type 1 allergy (relative risk [RR], 4.9 [2.9-8.4]), followed by a family history of asthma (RR, 2.83 [1.8-4.5]). Living with a cat was inversely related both to having a positive skin test to cat (1111, 0.62 [0.47-0.83]) and incidence of physician-diagnosed asthma (1111, 0.49 [0.28-0.83]). This effect on incident asthma was most pronounced among the children with a family history of asthma (RR, 0.25 [0.08-0.80]). The evidence also suggests that many of the children exposed to cats at home can develop an immune response that does not include immunoglobulin E. Weaker protective trends were seen with dog ownership. The traditional thinking that not owning cats can provide protection against developing allergy and asthma among those with a family history of allergy needs to be re-evaluated. In a community where cat sensitization was strongly associated with asthma, owning a cat was protective against both prevalent and incident asthma.