Elevate concentrazioni sieriche di antigene carcinoembrionario in corso di ipotiroidismo
Elevate concentrazioni sieriche di antigene carcinoembrionario in corso di ipotiroidismo
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提高 ipotiroidismo 抗原癌胚浓度
DOI：
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发表时间：
2004
影响因子：
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通讯作者：
Sara Bonizzato
中科院分区：
文献类型：
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作者：
Giorgio Bertola;Gianni Balza;Alessandro Oriani;Daniela Morganti;Claudiano Sironi;Sara Bonizzato
在这个病例报告中，我们描述了两例甲状腺功能减退和癌胚抗原（CEA）血清浓度升高的患者。前者为原发性自身免疫性甲状腺功能减退症患者，后者为空蝶鞍综合征继发性甲状腺功能减退症患者。在两例患者中，我们均未发现肿瘤病变的证据，并且在患者接受l -甲状腺素激素替代治疗后，CEA血清浓度几乎完全恢复到正常范围值。虽然文献中已经报道了甲状腺功能减退与CEA血清浓度升高的关系，但当医生面对CEA水平升高的患者时，通常会忽略甲状腺功能减退。相反，我们的数据表明，在这些患者的诊断工作中应考虑到甲状腺功能减退，如吸烟、胆汁淤积、肝功能受损、慢性炎症性支气管和肠道疾病。
In this case-report we describe two patients with hypothyroidism and increased carcinoembryonic antigen (CEA) serum concentration. The former patient was a woman affected by primary autoimmune hypothyroidism, the latter by secondary hypothyroidism in empty sella syndrome. In both of the patients we found no evidence of neoplastic disease and CEA serum concentrations reverted almost completely to the normal range values after the patients were given the hormonal replacement therapy with L-thyroxine. Although the association of hypothyroidism with elevated CEA serum concentrations has been already reported in the literature, hypothyroidism is usually disregarded when a physician is facing with a patient with increased CEA levels. On the contrary, our data suggest that hypothyroidism should be taken into account in the diagnostic work-up of these patients, such as smoking, cholestasis, impaired liver function, chronic inflammatory bronchial and bowel disease.