The changing pattern of inhaled nitric oxide use in the neonatal intensive care unit
The changing pattern of inhaled nitric oxide use in the neonatal intensive care unit
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DOI：
10.1038/jp.2010.37
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发表时间：
2010-12-01
影响因子：
2.9
通讯作者：
Spitzer, A. R.
中科院分区：
文献类型：
--
作者：
Clark, R. H.;Ursprung, R. L.;Spitzer, A. R.
目的：本研究的目的是评估2000-08年间入住新生儿重症监护室并接受吸入性一氧化氮（iNO）治疗的新生儿的人口统计学特征和结局。研究这组新生儿的目的是评估如何iNO的使用在婴儿中的演变，并估计该药物在此population.Study设计的标签外使用的频率：Pediatrix临床数据仓库去识别数据集的回顾性审查。Pediatrix医疗集团在32个州和波多黎各的244家医院提供重症监护服务。9个（3.7%）中心提供体外膜肺氧合。结果：数据集中有494255名新生儿; 4316名（0.9%）接受iNO治疗。iNO的使用从2000年的32967例患者中的154例增加到2008年的75911例患者中的921例;增加了2.6倍（0.47%至1.23%）。有155 872名婴儿
Objective: The purpose of this study was to evaluate the demographic characteristics and outcomes of neonates who were admitted to a neonatal intensive care unit and treated with inhaled nitric oxide (iNO) during the years 2000-08. The goal of studying this group of neonates was to evaluate how iNO use has evolved in infants and to estimate the frequency of off-label use of this drug in this population.Study Design: Retrospective review of the Pediatrix Clinical Data Warehouse de-identified data set. Pediatrix Medical Group provides intensive care services in 244 hospitals in 32 states and Puerto Rico. Nine (3.7%) centers provide extracorporeal membrane oxygenation.Result: There were 494 255 neonates in the data set; 4316 (0.9%) were treated with iNO. The use of iNO increased from 154 of 32 967 patients in 2000 to 921 of 75 911 patients in 2008; a 2.6-fold increase (0.47 to 1.23%). There were 155 872 infants