Uniform-sized molecularly imprinted polymer for (S)-ibuprofen retention properties in aqueous mobile phases.
Uniform-sized molecularly imprinted polymer for (S)-ibuprofen retention properties in aqueous mobile phases.
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DOI：
10.1016/s0021-9673(99)00764-5
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发表时间：
1999-10
期刊：
影响因子：
--
通讯作者：
J. Haginaka;H. Sanbe;H. Takehira
中科院分区：
文献类型：
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作者：
J. Haginaka;H. Sanbe;H. Takehira
以4-乙烯基吡啶（4-VPY）和乙二醇二甲基丙烯酸酯（EDMA）分别作为主体功能单体和交联剂，采用多步溶胀热聚合法制备了尺寸均一的布洛芬分子印迹聚合物。采用水溶液洗脱，用高效液相色谱（HPLC）法对所得到的（S）-布洛芬分子印迹材料进行了评价。布洛芬对映体与4-VPY-EDMA材料之间的疏水作用和氢键作用对布洛芬对映体的保留性和对映体选择性起着重要作用。此外，布洛芬代谢物2-羟基-和2-羧基-布洛芬的对映体的部分拆分实现了（S）-布洛芬印迹4-VPY-EDMA材料。
A uniform-sized molecularly imprinted polymer for (S)-ibuprofen has been prepared by a multi-step swelling and thermal polymerization method using 4-vinylpyridine (4-VPY) and ethylene glycol dimethacrylate (EDMA) as a host functional monomer and cross-linker, respectively. The obtained (S)-ibuprofen imprinted 4-VPY–EDMA materials were evaluated using aqueous eluents by HPLC. Hydrophobic and hydrogen bonding interactions between ibuprofen enantiomers and 4-VPY–EDMA materials could play an important role in the retentivity and enantioselectivity. Further, partial resolution of the enantiomers of ibuprofen metabolites, 2-hydroxy- and 2-carboxyibuprofen, was attained with the (S)-ibuprofen imprinted 4-VPY–EDMA materials.