Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis
Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis
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DOI：
10.1177/1352458508097923
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发表时间：
2009-02-01
影响因子：
5.8
通讯作者：
Kira, J. I.
中科院分区：
文献类型：
--
作者：
Kawajiri, M.;Mogi, M.;Kira, J. I.
目的和方法检测20例MS患者和17例非神经系统疾病患者脑脊液中血管紧张素转换酶(ACE)、血管紧张素转换酶2(ACE2)和血管紧张素II的浓度。结果MS患者脑脊液中血管紧张素转换酶(ACE)水平显著高于对照组(48.42+/-4.84vs44.71+/-3.9pg/mL)；而ACE2水平显著降低(2.56+/-0.26vs2.78+/-0.24pg/mLvs 2.78+/-0.24pg/mLvs2.78+/-0.24pg/mLACE2)，血管紧张素II水平趋于正常化。15：262-265。Http://msj.sagepub.com
Background We reported a reduction in the levels of angiotensin II in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS).Objective and methods To clarify the mechanism underlying this reduction, we assayed angiotensin-converting enzyme (ACE) and ACE2 concentrations along with angiotensin II concentrations in CSF samples from 20 patients with MS and 17 controls with non-neurological diseases.Results ACE levels were significantly elevated in patients with MS compared with controls (48.42 +/- 4.84 vs 44.71 +/- 3.9 pg/mL), whereas ACE2 levels were significantly reduced (2.56 +/- 0.26 vs 2.78 +/- 0.24 pg/mL), acting toward a normalization of angiotensin II levels.Conclusion These results further indicate an alteration of the intrathecal renin-angiotensin system in patients with MS. Multiple Sclerosis 2009; 15: 262-265. http://msj.sagepub.com