Partial fatty acid oxidation (pFOX) inhibition: A new therapy for chronic stable angina
Partial fatty acid oxidation (pFOX) inhibition: A new therapy for chronic stable angina
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DOI：
10.1002/clc.4960260402
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发表时间：
2003-04
影响因子：
2.7
通讯作者：
C. Conti
中科院分区：
文献类型：
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作者：
C. Conti
在心肌缺血期间，脂肪酸是主要的能量来源，会增加心肌耗氧量并使冠状动脉血流量的减少难以耐受。心肌缺血期间增加葡萄糖氧化可以提高心脏效率。 pFOX 抑制剂有潜力实现这一目标。 2003 年，我认为我们可以期待更多地了解这一类称为 pFOX 抑制剂的化合物。也许他们将为我们的患者提供替代疗法，这些患者尽管接受了积极的药物治疗和/或血运重建，但仍患有持续性慢性稳定型心绞痛。在我看来，这是一个日益严重的问题，在想要保持活跃但慢性稳定性心绞痛干扰了这种生活方式的老年患者中尤其常见。
During myocardial ischemia, fatty acids are the principal source of energy, increasing myocardial oxygen consumption and making a decrease in coronary blood flow less well tolerated. Increasing glucose oxidation during myocardial ischemia may improve cardiac efficiency. The pFOX inhibitors have the potential to accomplish this. In 2003, I think we can look forward to learning more about this class of compounds called pFOX inhibitors. Perhaps they will provide us alternative therapies in our patients who have persistent chronic stable angina pectoris despite aggressive medical therapy and/or revascularization. It seems to methat this is an increasing problem, and it is particularly common in older patients who want to remain active, but whose chronic stable angina interferes with that lifestyle.