Carotid plaque signal differences among four kinds of T1-weighted magnetic resonance imaging techniques: A histopathological correlation study
Carotid plaque signal differences among four kinds of T1-weighted magnetic resonance imaging techniques: A histopathological correlation study
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DOI：
10.1007/s00234-012-1025-9
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发表时间：
2012-11-01
期刊：
影响因子：
2.8
通讯作者：
Terayama, Yasuo
中科院分区：
文献类型：
--
作者：
Saito, Ayumi;Sasaki, Makoto;Terayama, Yasuo
多种磁共振 (MR) 成像技术可用于检查颈动脉的粥样硬化斑块；然而，可视化斑块内特征的最佳技术尚未确定。在这里，我们直接比较了四种T1加权（T1W）成像技术与颈动脉狭窄患者的病理结果。使用1.5-T MRI扫描仪对总共31名候选颈动脉内膜切除术的患者进行了前瞻性检查，产生了四种T1W图像，包括非门控自旋回波（SE）、心门控黑血（BB）快速SE（FSE）、磁化准备梯度快速采集回波 (MPRAGE) 和三维飞行时间 MR 血管造影 (SI-MRA) 源图像。手动测量颈动脉斑块的信号强度，并计算与邻近肌肉的对比度（CR）。将四种成像技术的 CR 相互比较，并与组织病理学标本相关。主要含有纤维组织、脂质/坏死和出血的颈动脉斑块的 CR 在非门控 SE 上差异显着，几乎没有重叠（范围分别为：0.92-1.15、1.22-1.52 和 1.55-2.30）。然而，BB-FSE 在三组之间显示出显着的重叠（分别为 0.89-1.10、1.07-1.23 和 1.01-1.42）。 MPRAGE 可以区分纤维斑块和出血斑块，但不能区分富含脂质/坏死的斑块：（分别为 0.77-1.07、1.45-2.43 和 0.85-1.42）。 SI-MRA 显示出相同的趋势（分别为 1.01-1.39、1.45-2.57 和 1.12-1.39）。 在 T1W MR 成像技术中，与心脏门控 BB-FSE、MPRAGE 和 SI-MRA 图像相比，非门控 SE 图像可以更准确地表征接受 CEA 的患者的斑块内成分。
Several magnetic resonance (MR) imaging techniques are used to examine atherosclerotic plaque of carotid arteries; however, the best technique for visualizing intraplaque characteristics has yet to be determined. Here, we directly compared four kinds of T1-weighted (T1W) imaging techniques with pathological findings in patients with carotid stenosis.A total of 31 patients who were candidates for carotid endarterectomy were prospectively examined using a 1.5-T MRI scanner, which produced four kinds of T1W images, including non-gated spin echo (SE), cardiac-gated black-blood (BB) fast-SE (FSE), magnetization-prepared rapid acquisition with gradient echo (MPRAGE), and source image of three-dimensional time-of-flight MR angiography (SI-MRA). The signal intensity of the carotid plaque was manually measured, and the contrast ratio (CR) against the adjacent muscle was calculated. CRs from the four imaging techniques were compared to each other and correlated with histopathological specimens.CRs of the carotid plaques mainly containing fibrous tissue, lipid/necrosis, and hemorrhage were significantly different with little overlaps (range: 0.92-1.15, 1.22-1.52, and 1.55-2.30, respectively) on non-gated SE. However, BB-FSE showed remarkable overlaps among the three groups (0.89-1.10, 1.07-1.23, and 1.01-1.42, respectively). MPRAGE could discriminate fibrous plaques from hemorrhagic plaques but not from lipid/necrosis-rich plaques: (0.77-1.07, 1.45-2.43, and 0.85-1.42, respectively). SI-MRA showed the same tendencies (1.01-1.39, 1.45-2.57, and 1.12-1.39, respectively).Among T1W MR imaging techniques, non-gated SE images can more accurately characterize intraplaque components in patients who underwent CEA when compared with cardiac-gated BB-FSE, MPRAGE, and SI-MRA images.