Risk Assessment for Sudden Death in Epilepsy: The SUDEP-7 Inventory
Risk Assessment for Sudden Death in Epilepsy: The SUDEP-7 Inventory
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DOI：
10.3389/fneur.2015.00252
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发表时间：
2015-12-09
影响因子：
3.4
通讯作者：
DeGiorgio, Christopher M.
中科院分区：
文献类型：
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作者：
Novak, Jennifer L.;Miller, Patrick R.;DeGiorgio, Christopher M.
背景：癫痫猝死(SUDEP)是耐药癫痫(DRE)患者的主要死亡原因。目的：探讨修订后的SUDEP风险量表(SUDEP-7)在DRE队列中的应用，并确定其与心率和其他协变量的关系。收集基本人口学资料、癫痫持续时间、发作类型、发作频率、发作严重程度、抗癫痫药物和生命体征。心率变异性(HRV)由1h的心电记录计算。实施了SUDEP风险清单(SUDEP-7)，其中包括Walczak等人最初确定的七个经过验证和加权的风险因素。结果：修订后的SUDEP-7总分范围为1~7，平均为3.4(SD 1.8)。SUDEP风险问卷得分与RMSSD呈负相关(Pearson r=-0.45，p=0.027)。以下变量与RMSSD显著相关：癫痫持续时间(p=0.02)、年龄(p=0.03)和发育性智能障碍(p
Background: Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in those with drug-resistant epilepsy (DRE). There is a need for inventories and biomarkers associated with the risk for SUDEP.Objective: To explore the revised SUDEP Risk Inventory (SUDEP-7) in a cohort with DRE and determine the association with Heart Rate and other covariates.Methods: Twenty-five subjects with severe DRE were enrolled in a clinical trial for epilepsy. Baseline demographics, duration of epilepsy, seizure types, seizure frequency, seizure severity, AEDs, and vital signs were collected. Heart rate variability (HRV) was calculated from 1-h recordings of ECG. A SUDEP Risk Inventory (SUDEP-7) was administered, which included seven validated and weighted risk factors initially identified by Walczak et al. as factors associated with SUDEP risk.Results: The total score on the revised SUDEP-7 ranged from 1 to 7, mean = 3.4 (SD 1.8). The SUDEP Risk Inventory score was inversely correlated with RMSSD (Pearson r = -0.45, p = 0.027). The following variables were significantly associated with RMSSD: epilepsy duration (p = 0.02), age (p = 0.03), and developmental intellectual disability (p