Dissociable stages of human memory consolidation and reconsolidation
Dissociable stages of human memory consolidation and reconsolidation
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DOI：
10.1038/nature01930
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发表时间：
2003-10-09
期刊：
影响因子：
64.8
通讯作者：
Stickgold, R
中科院分区：
文献类型：
--
作者：
Walker, MP;Brakefield, T;Stickgold, R
在历史上，记忆巩固这个术语指的是随着时间的推移，记忆对竞争或干扰因素的干扰变得越来越抵抗的过程(1)。最近关于熟练的感觉和运动任务的学习(程序学习)的发现完善了这一定义，表明巩固可以更严格地由在特定大脑状态中花费的时间来确定，如清醒、睡眠或睡眠的特定阶段(2-8)。人们还对重新唤起或重新激活先前巩固的记忆的可能性重新产生了兴趣(9)，这可能会使它再次变得脆弱和容易受到干扰(10-12)，因此需要重新巩固(13-15)。使用运动技能手指敲击任务，我们在这里提供了在最初习得之后人类运动记忆处理的至少三个不同阶段的证据。我们描述了觉醒和睡眠在不同形式的巩固发展中的独特贡献，并表明清醒重新激活可以将先前巩固的记忆重新转变为需要随后重新巩固的不稳定状态。
Historically, the term 'memory consolidation' refers to a process whereby a memory becomes increasingly resistant to interference from competing or disrupting factors with the continued passage of time(1). Recent findings regarding the learning of skilled sensory and motor tasks ('procedural learning') have refined this definition, suggesting that consolidation can be more strictly determined by time spent in specific brain states such as wake, sleep or certain stages of sleep(2-8). There is also renewed interest(9) in the possibility that recalling or 'reactivating' a previously consolidated memory renders it once again fragile and susceptible to interference(10-12), therefore requiring periods of reconsolidation(13-15). Using a motor skill finger-tapping task, here we provide evidence for at least three different stages of human motor memory processing after initial acquisition. We describe the unique contributions of wake and sleep in the development of different forms of consolidation, and show that waking reactivation can turn a previously consolidated memory back into a labile state requiring subsequent reconsolidation.