Effects of dehydration on the rate of proliferation of hypothalamic neuroglia cells.
Effects of dehydration on the rate of proliferation of hypothalamic neuroglia cells.
复制标题
脱水对下丘脑神经胶质细胞增殖率的影响。
DOI：
10.1016/0014-4886(68)90087-3
复制
发表时间：
1968
影响因子：
5.3
通讯作者：
M. Murray
中科院分区：
文献类型：
--
作者：
M. Murray
应用放射自显影技术研究了渗透压刺激对大鼠下丘脑神经胶质细胞增殖速率的影响。五只动物作为对照，四只大鼠通过饮用1%的盐水溶液脱水14天。在14天的治疗期间，每天向动物注射3 H-胸苷。标记的神经胶质细胞的数量显着增加发生在视上核和垂体后叶的脱水大鼠，而对照组和脱水动物的正中隆起和漏斗干，视神经，或三叉神经和神经节的标记细胞的百分比没有显着差异。因此，脱水似乎是视上核和垂体后叶神经胶质增生的刺激因素。
Radioautographic techniques were used to study the effects of osmotic stimuli on the rate of proliferation of neuroglia cells in the hypothalamus of the rat. Five animals served as controls and four rats were dehydrated by drinking a 1% saline solution for 14 days. The animals were injected with3H-thymidine each day during the 14 days of treatment. Significant increases in the numbers of labeled neuroglia cells occurred in the supraoptic nucleus and posterior pituitary of dehydrated rats while there were no significant differences between control and dehydrated animals in the percentages of labeled cells in the median eminence and infundibular stem, the optic nerve, or the trigeminal nerve and ganglion. Dehydration thus appears to act as a stimulus to glial proliferation in the supraoptic nucleus and posterior pituitary.