Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur Studies of Successful Aging
Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur Studies of Successful Aging
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DOI：
10.1093/gerona/55.12.m709
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发表时间：
2000-12-01
影响因子：
5.1
通讯作者：
Seeman, TE
中科院分区：
文献类型：
--
作者：
Taaffe, DR;Harris, TB;Seeman, TE
背景资料。慢性炎症被认为是随着年龄增长而导致身体功能下降的一种生物学机制。本研究的目的是研究炎症标志物、白介素6(IL-6)和C反应蛋白(CRP)之间的横断面和前瞻性关系，并对70-79岁老年人的体能进行多项测量。受试者是参加麦克阿瑟成功老龄化研究(n=1189)的880名高功能男性和女性，这是老年人流行病学研究(n=4030)既定人群的一个子集。采用双抗体夹心法测定血浆IL-6和CRP水平，LOG变换对分布进行归一化处理。身体功能测量包括握力、签名时间、椅子站立(完成5次重复的时间)和6米步行时间。女性较低(p<0.05)。
Background. Chronic inflammation has been proposed as a biological mechanism underlying the decline in physical function that occurs with aging. The purpose of this investigation was to examine the cross-sectional and prospective relationships between markers of inflammation, interleukin-6 (IL-6) and C-reactive protein (CRP), with several measures of physical performance in older persons aged 70 to 79 years.Methods. Subjects were 880 high-functioning men and women participating in the MacArthur Study of Successful Aging (n = 1189), a subset of the Established Populations for Epidemiologic Studies of the Elderly (n = 4030). Plasma IL-6 and CRP levels were determined by enzyme linked immunosorbent assay and log transformed to normalize the distributions. Physical function measures included handgrip strength, signature time, chair stands (time to complete five repetitions), and 6-m walk time.Results. Women had lower (p