Post-Translational Modification of MRE11: Its Implication in DDR and Diseases.
Post-Translational Modification of MRE11: Its Implication in DDR and Diseases.
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DOI：
10.3390/genes12081158
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发表时间：
2021-07-28
期刊：
影响因子：
3.5
通讯作者：
Zhou ZW
中科院分区：
文献类型：
--
作者：
Lu R;Zhang H;Jiang YN;Wang ZQ;Sun L;Zhou ZW
维持基因组稳定性对细胞和个体生物至关重要。减数分裂重组相关基因MRE 11（meiotic recombination 11）通过其在断裂DNA末端的切除、DNA损伤反应（DDR）、DNA双链断裂（DSB）修复和端粒维持中的重要作用而对保持基因组稳定性至关重要。翻译后修饰（PTMs），如磷酸化、泛素化和甲基化，直接调节MRE 11的功能，使MRE 11能够迅速、准确、多样化地响应细胞过程。在本文中，我们主要关注MRE 11的PTM及其在DNA应答和修复，维持基因组稳定性中的作用，以及它们与癌症等疾病的关系。
Maintaining genomic stability is vital for cells as well as individual organisms. The meiotic recombination-related gene MRE11 (meiotic recombination 11) is essential for preserving genomic stability through its important roles in the resection of broken DNA ends, DNA damage response (DDR), DNA double-strand breaks (DSBs) repair, and telomere maintenance. The post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and methylation, regulate directly the function of MRE11 and endow MRE11 with capabilities to respond to cellular processes in promptly, precisely, and with more diversified manners. Here in this paper, we focus primarily on the PTMs of MRE11 and their roles in DNA response and repair, maintenance of genomic stability, as well as their association with diseases such as cancer.
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影响因子：
14.9
作者：
Chen YJ;Chuang YC;Chuang CN;Cheng YH;Chang CR;Leng CH;Wang TF
通讯作者：
Wang TF
影响因子：
3.8
作者：
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作者：
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DOI：
10.1073/pnas.1306328110
发表时间：
2013-12-17
影响因子：
11.1
作者：
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通讯作者：
Kornbluth, Sally
影响因子：
16.8
作者：
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通讯作者：
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