Carbon dots as a trackable drug delivery carrier for localized cancer therapy in vivo
Carbon dots as a trackable drug delivery carrier for localized cancer therapy in vivo
复制标题
碳点作为可追踪的药物输送载体，用于体内局部癌症治疗
DOI：
10.1039/c6tb01259k
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发表时间：
2016-01-01
影响因子：
7
通讯作者：
Li, Qin
中科院分区：
文献类型：
--
作者：
Zeng, Qinghui;Shao, Dan;Li, Qin
荧光碳点（CDs）具有小于10nm的尺寸，良好的生物相容性和低至无细胞毒性，被认为是纳米医学的一颗新星。在本报告中，我们首次证明了具有富含羧基表面的绿色发光cd可以用作可追踪的药物递送剂，用于小鼠模型的局部癌症治疗。CDs通过非共价键与抗癌药物阿霉素（DOX）结合，利用CDs上的天然羧基和DOX分子上的胺部分。癌细胞和正常细胞之间的pH值差异被成功地利用作为DOX释放的触发机制。我们的体内研究表明，荧光CDs可以作为局部治疗的靶向药物递送系统，并且纳米点载体与药物分子之间的刺激响应非共价键在复杂的生物系统中足够稳定。总之，我们的工作为促进cd在癌症治疗中的潜在临床应用提供了一种策略。
Fluorescent carbon dots (CDs) with a size smaller than 10 nm, excellent biocompatibility, and low to no cytotoxicity are considered as a rising star in nanomedicine. In this report, for the first time we demonstrate that green-emitting CDs with a carboxyl-rich surface can be employed as a trackable drug delivery agent for localized cancer treatment in a mouse model. The CDs are conjugated with the cancer drug, Doxorubicin (DOX), via non-covalent bonding, utilizing the native carboxyl groups on CDs and the amine moiety on DOX molecules. The pH difference between cancer and normal cells was successfully exploited as the triggering mechanism for DOX release. Our in vivo study demonstrated that the fluorescent CDs can serve as a targeted drug delivery system for localized therapy, and the stimuli-responsive non-covalent bonding between the nanodot carrier and the drug molecule is sufficiently stable in complex biological systems. Taken together, our work provides a strategy to promote the potential clinical application of CDs in cancer theranostics.