Prediction of outcome in asphyxiated newborns treated with hypothermia: Is a MRI scoring system described before the cooling era still useful?
Prediction of outcome in asphyxiated newborns treated with hypothermia: Is a MRI scoring system described before the cooling era still useful?
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DOI：
10.1016/j.ejpn.2018.01.017
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发表时间：
2018-05-01
影响因子：
3.1
通讯作者：
Wintermark, Pia
中科院分区：
文献类型：
--
作者：
Al Amrani, Fatema;Marcovitz, Jaclyn;Wintermark, Pia
目的：为了确定是否MRI评分系统，这是在预冷时代验证，仍然可以预测窒息新生儿的神经发育结果与低温治疗2岁的age.Patients和方法：我们进行了一项回顾性队列研究窒息新生儿低温治疗。使用在预冷时代验证的MRI评分系统对新生儿脑MRI上的脑损伤严重程度进行分级。他们的神经发育进行了评估约2岁;不良后果包括脑瘫，全球发展迟缓，和/或epilepsy.Results：一百六十九名新生儿被列入。在131名存活并在新生儿期进行脑部MRI的新生儿中，92%的新生儿在2岁或更大时接受了评估。在这些新生儿中，37%表现出脑损伤，23%出现不良结局。窒息的新生儿低温治疗谁有不良后果有显着较高的MRI评分（p < 0.001）相比，那些没有一个不利outcome.Conclusion：MRI评分系统，验证前冷却时代仍然能够可靠地区分哪些窒息的新生儿低温治疗更容易发展的不良后果约2岁。(C)2018年欧洲儿科神经病学学会。由爱思唯尔有限公司出版。保留所有权利。
Aim: To determine whether an MRI scoring system, which was validated in the pre-cooling era, can still predict the neurodevelopmental outcome of asphyxiated newborns treated with hypothermia at 2 years of age.Patients and method: We conducted a retrospective cohort study of asphyxiated newborns treated with hypothermia. An MRI scoring system, which was validated in the pre-cooling era, was used to grade the severity of brain injury on the neonatal brain MRI. Their neurodevelopment was assessed around 2 years of age; adverse outcome included cerebral palsy, global developmental delay, and/or epilepsy.Results: One hundred and sixty-nine newborns were included. Among the 131 newborns who survived and had a brain MRI during the neonatal period, 92% were evaluated around 2 years of age or later. Of these newborns, 37% displayed brain injury, and 23% developed an adverse outcome. Asphyxiated newborns treated with hypothermia who had an adverse outcome had a significantly higher MRI score (p < 0.001) compared to those without an adverse outcome.Conclusion: An MRI scoring system that was validated before the cooling era is still able to reliably differentiate which of the asphyxiated newborns treated with hypothermia were more prone to develop an adverse outcome around 2 years of age. (C) 2018 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.