Micromanipulation of embryos and germ cells: an approach to gene therapy?
Micromanipulation of embryos and germ cells: an approach to gene therapy?
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胚胎和生殖细胞的显微操作：基因治疗的一种方法？
DOI：
10.1002/ajmg.1320350213
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Gordon,JW
中科院分区：
文献类型：
--
作者：
Gordon,JW
哺乳动物配子和胚胎显微操作的最新进展刺激了科学界和医学界，在某种程度上也刺激了广大公众，使他们意识到通过直接改变遗传密码来治疗遗传疾病可能很快就会成为可能。由于这些显微操作技术导致在发育的最早阶段基因型的改变，这种“基因治疗”不仅影响孕体本身，而且影响其生殖细胞。因此，这种遗传修饰是可遗传的，并且可以无限期地传递给后代。在演讲中，基因治疗的狭义和广义定义将根据其所基于的技术，其治疗遗传疾病的潜力及其目前的可行性进行考虑。
Recent advances in mammalian gamete and embryo micromanipulation have stimulated the scientific and medical communities, and to some degree the public at large, to become aware that treatment of genetic disease by direct alteration of the genetic code may soon be possible. Because these micromanipulation techniques result in modification of the genotype at the earliest stages of development, such “gene therapy” affects not only the conceptus itself but also its germ cells. Thus such genetic modifications are heritable and can be transmitted indefinitely to succeeding generations of progeny. In the presentation, both narrow and broad definitions of gene therapy will be considered with respect to the techniques upon which they are based, their potential for treatment of genetic disease, and their current feasibility.