Prenatal phthalate exposure and infant size at birth and gestational duration.
Prenatal phthalate exposure and infant size at birth and gestational duration.
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DOI：
10.1016/j.envres.2016.05.033
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发表时间：
2016-10
影响因子：
8.3
通讯作者：
Braun JM
中科院分区：
文献类型：
--
作者：
Shoaff JR;Romano ME;Yolton K;Lanphear BP;Calafat AM;Braun JM
邻苯二甲酸盐接触现象很普遍。先前的研究表明，产前接触邻苯二甲酸盐可能会影响出生尺寸和妊娠持续时间，但已发表的结果并不一致。我们量化了母亲尿液中邻苯二甲酸盐浓度与婴儿出生体重 z 分数、身长、头围和妊娠持续时间之间的关系。在俄亥俄州辛辛那提 HOME 研究的 368 名女性队列中，我们测量了 9 种邻苯二甲酸酯代谢物，这些代谢物代表了在妊娠 16 周和 26 周左右收集的尿液中接触到的六种邻苯二甲酸二酯母体。婴儿出生大小和妊娠持续时间是从医疗记录中提取的。我们使用多变量线性回归来估计尿邻苯二甲酸酯代谢物浓度与婴儿结局之间的协变量调整关联。在未经调整的模型中，我们观察到邻苯二甲酸单乙酯（MEP）与出生体重 z 分数之间呈负相关，而邻苯二甲酸单-3-羧丙酯（MCPP）与妊娠持续时间呈正相关。协变量调整后，邻苯二甲酸酯代谢物浓度不再与出生体重或妊娠持续时间相关。在该队列中，怀孕期间尿邻苯二甲酸酯代谢物浓度与婴儿出生大小或妊娠持续时间无关。需要进行更多研究来确定胎儿发育早期的暴露是否与婴儿健康相关。
Phthalate exposure is widespread. Prior research suggests that prenatal phthalate exposure may influence birth size and gestational duration, but published results have been inconsistent. We quantified the relationship between maternal urinary phthalate concentrations and infant birth weight z-scores, length, head circumference, and gestational duration. In a cohort of 368 women from the HOME Study, based in Cincinnati, OH, we measured nine phthalate metabolites representing exposure to six parent phthalate diesters in urine collected at approximately 16 and 26 weeks gestation. Infant birth size and gestational duration were abstracted from medical records. We used multivariable linear regression to estimate covariate adjusted associations between urinary phthalate metabolite concentrations and infant outcomes. In unadjusted models, we observed a negative association between monoethyl phthalate (MEP) and birth weight z-scores, while mono-3-carboxypropyl phthalate (MCPP) was positively associated with gestational duration. After covariate adjustment, phthalate metabolite concentrations were no longer associated with birth size or gestational duration. In this cohort, urinary phthalate metabolites concentrations during pregnancy were not associated with infant birth size or gestational duration. Additional research is needed to determine if exposures during earlier periods of fetal development are associated with infant health.