Incidence and prevalence of cirrhosis in the United Kingdom, 1992-2001: A general population-based study
Incidence and prevalence of cirrhosis in the United Kingdom, 1992-2001: A general population-based study
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DOI：
10.1016/j.jhep.2008.05.023
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发表时间：
2008-11-01
影响因子：
25.7
通讯作者：
West, Joe
中科院分区：
文献类型：
--
作者：
Fleming, Kate M.;Aithal, Guruprasad P.;West, Joe
背景/目标：为了确定肝硬化的发病率和患病率在英国。方法：我们确定了25岁或以上的肝硬化，食管静脉曲张或门静脉高压症的患者从英国全科医学研究数据库在1992年和2001年之间。我们按性别、年份和病因测量发病率、发病率比率和估计患病率。粗发病率为14.55/100 000人年，从1992年的12.05/100 000人年增加到2001年的16.99/100 000人年。男性的发病率比女性高50%以上（校正后的发病率比为1.52（95%CI [1.42-1.63]））。酒精性肝硬化和非酒精性肝硬化的发病率在男性和女性中均有统计学显著性增加。在2001年中期，25岁以上人群中肝硬化的患病率估计为76.3/100，000。结论：在1992-2001年的十年间，英国肝硬化的发病率增加了45%，患病率增加了68%。肝硬化发生在男性比女性更常见和更年轻。肝硬化是英国发病率和死亡率不断增长的负担，估计有30，000人患有肝硬化，每年至少有7000例新病例被诊断出来。(C)2008年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: To determine the incidence and prevalence of cirrhosis in the United Kingdom.Methods: We identified patients aged 25 or over with cirrhosis, oesophageal varices or portal hypertension from the UK General Practice Research Database between 1992 and 2001. We measured incidence rates by sex, year and aetiology, incidence rate ratios and estimated prevalence figures.Results: Three thousand three hundred and sixty cases of cirrhosis were identified. Crude incidence was 14.55 per 100,000 person years increasing from 12.05 to 16.99 per 100,000 person years from 1992 to 2001. Incidence was over 50% higher in men compared with women (adjusted incidence rate ratio 1.52 (95%CI [1.42-1.63])). A statistically significant increase in incidence of both alcoholic cirrhosis and non-alcohol-related cirrhosis was seen in men and women. Prevalence of cirrhosis was an estimated 76.3 per 100,000 population aged over 25 in mid-2001.Conclusions: There was a 45% increase in the incidence of cirrhosis during the decade 1992-2001 in the UK and a 68% increase in prevalence. Cirrhosis occurred more commonly and at younger ages in men than women. Cirrhosis represents a growing burden of morbidity and mortality in the UK, with an estimated 30,000 people living with cirrhosis and at least 7000 new cases being diagnosed each year. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.