Usefulness of flow-mediated dilation of the brachial artery and/or the intima-media thickness of the carotid artery in predicting coronary narrowing in patients suspected of having coronary artery disease
Usefulness of flow-mediated dilation of the brachial artery and/or the intima-media thickness of the carotid artery in predicting coronary narrowing in patients suspected of having coronary artery disease
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DOI：
10.1016/s0002-9149(01)02051-3
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发表时间：
2001-11-15
影响因子：
2.8
通讯作者：
Chayama, K
中科院分区：
文献类型：
--
作者：
Teragawa, H;Kato, M;Chayama, K
据报道，动脉粥样硬化标志物肱动脉血流介导扩张（FMD）和颈动脉内膜-中膜厚度（IMT）在冠状动脉疾病（CAD）患者中发生改变，但目前尚不清楚这些标志物是否可以检测到CAD的存在。我们研究了是否可以通过肱动脉FMD和/或IMT检测到CAD的存在。81例首次接受冠状动脉造影的患者被纳入研究。在冠状动脉造影前，使用高分辨率超声（10 MHz）测量每位患者肱动脉直径对FMD和硝酸甘油喷雾的反应，以及颈动脉IMT。冠心病定义为冠状动脉主干狭窄50%。56例患者患有CAD。CAD患者FMD较低，IMT较高(FMD, 2.9 +/-0.2% vs 9.4 +/-0.5%； IMT, 1.09 +/-0.05 vs 0.79 +/-0.04 mm，均p
It has been reported that flow-mediated dilation (FMD) of the brachial artery and the carotid intima-media thickness (IMT), markers of atherosclerosis, are altered in patients with coronary artery disease (CAD), but it is still not known if the presence of CAD can be detected using these markers. We examined whether the presence of CAD can be detected by FMD of the brachial artery and/or IMT. Eighty-one patients who underwent coronary angiography for the first time were enrolled. In each patient, brachial artery diameter responses to FMD and the administration of nitroglycerin spray, and carotid IMT were measured using high-resolution ultrasound (10 MHz) before coronary angiography. CAD was defined as >50% stenosis of a major coronary artery. Fifty-six patients had CAD. FMD was lower and IMT was greater in patients with CAD (FMD, 2.9 +/-0.2% vs 9.4 +/-0.5%; IMT, 1.09 +/-0.05 vs 0.79 +/-0.04 mm, both p