BILE-ACIDS AND COLONIC MOTILITY IN RABBIT AND HUMAN .1. RABBIT
BILE-ACIDS AND COLONIC MOTILITY IN RABBIT AND HUMAN .1. RABBIT
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DOI：
10.1136/gut.16.11.894
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发表时间：
1975-01-01
期刊：
影响因子：
24.5
通讯作者：
EASTWOOD, MA
中科院分区：
文献类型：
--
作者：
KIRWAN, WO;SMITH, AN;EASTWOOD, MA
将胆盐注入麻醉兔的盲肠或直肠，可启动结肠运动。对结肠近端和远端的初级胆汁酸进行检测，并引起明显的运动反应。由于二羟基胆汁酸被认为是结肠中电解质和水吸收的有效抑制剂，次要胆汁酸脱氧胆酸是与胆酸关系最密切的二羟基化合物，胆酸是兔体内的主要胆汁酸，在远端也被检测到，也是活性的，但程度低于胆酸结合物。在人类中，发现粪便胆汁酸的排泄和结肠运动之间的关系：胆汁酸直接进入人的乙状结肠和直肠也刺激了结肠的运动。在人体内，二羟基化合物鹅去氧胆酸的活性略高于胆酸的结合物。
Colonic motor activity was initiated by infusions of bile salts into the caecum or rectum of the anaesthetized rabbit. Primary bile acids were examined proximally and distally in the colon and elicited marked motor responses. Sinc dihydroxy bile acids are known to be potent inhibitors of electrolyte and water absorption in the colon, the secondary bile acid deoxycholic acid, the dihydroxyl compound most related to cholic acid which is the main bile acid in the rabbit, was examined distally and was also active, but to a lesser extent than cholic acid conjugates in this species. In man, a relationship was found between the faecal bile acid excretion and colonic motility: the introduction of bile acids directly into the human sigmoid colon and rectum also stimulated colonic motility. In man, the dihydroxy compound chenodeoxycholic acid was slightly more active than conjugates of cholic acid.