Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: A randomized, controlled trial
Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: A randomized, controlled trial
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DOI：
10.1681/asn.2006010034
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发表时间：
2006-08-01
影响因子：
13.6
通讯作者：
Shubert, Tiffany
中科院分区：
文献类型：
--
作者：
Johansen, Kirsten L.;Painter, Patricia L.;Shubert, Tiffany
正在进行血液透析的患者通常会出现肌肉萎缩和虚弱，这会对身体功能和生活质量产生负面影响。本研究的目的是确定在接受维持性血液透析的患者中，给予合成类固醇和阻力运动训练是否会导致合成代谢的影响。对在加州大学旧金山分校附属透析病房接受维持性血液透析的79名患者进行了合成类固醇应用和阻力运动训练的随机2×2析因试验。干预措施包括每周双盲服用地塞米松(女性为100毫克，男性为200毫克)或安慰剂注射，并在血液透析期间进行为期12周的下肢阻力运动训练，每周三次，使用脚踝重量。主要结果包括双能X射线吸收测量仪测量的瘦体重(LBM)的变化，磁共振成像测量的股四头肌横截面积，以及膝关节伸肌力量。次要结果包括身体表现、自我报告的身体功能和身体活动的变化。68名患者完成了这项研究。服用己酸诺龙的患者体重增加3.1%/2.2kg.(P<；0.0001)。运动并没有导致LBM的显著增加。在被分配到运动组(P=0.0001)和诺酮(P<；0.0001)的患者中，股四头肌横截面积以相加的方式增加。锻炼的患者以特定于锻炼的方式增加力量，锻炼与自我报告的身体功能的改善有关(与不锻炼组相比，P=0.04)。地塞米松和阻力运动在血液透析患者中产生了合成代谢的影响。需要进一步的研究来确定这些干预措施是否可以提高存活率。
Patients who are on hemodialysis commonly experience muscle wasting and weakness, which have a negative effect on physical functioning and quality of life. The objective of this study was to determine whether anabolic steroid administration and resistance exercise training induce anabolic effects among patients who receive maintenance hemodialysis. A randomized 2 X 2 factorial trial of anabolic steroid administration and resistance exercise training was conducted in 79 patients who were receiving maintenance hemodialysis at University of California, San Francisco-affiliated dialysis units. Interventions included double-blinded weekly nandrolone decanoate (100 mg for women; 200 mg for men) or placebo injections and lower extremity resistance exercise training for 12 wk during hemodialysis sessions three times per week using ankle weights. Primary outcomes included change in lean body mass (LBM) measured by dual-energy x-ray absorptiometry, quadriceps muscle cross-sectional area measured by magnetic resonance imaging, and knee extensor muscle strength. Secondary outcomes included changes in physical performance, self-reported physical functioning, and physical activity. Sixty-eight patients completed the study. Patients who received nandrolone decanoate increased their LBM by 3.1 +/- 2.2 kg (P < 0.0001). Exercise did not result in a significant increase in LBM. Quadriceps muscle cross-sectional area increased in patients who were assigned to exercise (P = 0.01) and to nandrolone (P < 0.0001) in an additive manner. Patients who exercised increased their strength in a training-specific fashion, and exercise was associated with an improvement in self-reported physical functioning (P = 0.04 compared with nonexercising groups). Nandrolone decanoate and resistance exercise produced anabolic effects among patients who were on hemodialysis. Further studies are needed to determine whether these interventions improve survival.