Neuropsychological deficits in schizophrenics. Relationship to age, chronicity, and dementia.
Neuropsychological deficits in schizophrenics. Relationship to age, chronicity, and dementia.
复制标题
DOI：
10.1001/archpsyc.1994.03950060033003
复制
发表时间：
1994-06
影响因子：
--
通讯作者：
R. Heaton;Jane S. Paulsen;L. Mcadams;J. Kuck;S. Zisook;D. Braff;J. Harris;D. Jeste
中科院分区：
文献类型：
--
作者：
R. Heaton;Jane S. Paulsen;L. Mcadams;J. Kuck;S. Zisook;D. Braff;J. Harris;D. Jeste
我们试图确定精神分裂症的神经心理学损害是否与当前年龄、发病年龄或病程有关，以及这种损害的模式是否可以与阿尔茨海默型进行性痴呆所引起的模式区分开来。我们管理一个全面的神经心理测试电池正常对照组（n = 38），一组门诊阿尔茨海默病患者（n = 42），和三个门诊精神分裂症组：早发年轻（n = 85），早发老年（n = 35），晚发（n = 22）。根据八个主要能力领域对测试进行分组和分析，并使用已公布的程序来消除正常老化的预期影响。结果三组精神分裂症患者的神经心理学特征相似，与正常对照组和阿尔茨海默病患者的神经心理学特征不同。精神分裂症组之间的神经心理功能的水平或模式没有显着差异。阿尔茨海默病患者表现出较低的学习效率，特别是比其他组更快的遗忘。结论：这些发现表明精神分裂症的神经心理损害与当前年龄、发病年龄或病程无关。这项研究进一步表明，与精神分裂症相关的脑病本质上是非进行性的，并产生一种与进行性皮质痴呆不同的缺陷模式。
BACKGROUND We sought to determine whether neuropsychological impairment in schizophrenia is related to current age, age at onset, or duration of illness, and whether the pattern of such impairment can be distinguished from that caused by progressive dementias of Alzheimer's type. We administered a comprehensive neuropsychological test battery to a normal control group (n = 38), a group of ambulatory patients with Alzheimer's disease (n = 42), and three ambulatory schizophrenic groups: early onset-young (n = 85), early onset-old (n = 35), and late onset (n = 22). Tests were grouped and analyzed according to eight major ability areas, and published procedures were used to remove the expected effects of normal aging. RESULTS The three schizophrenic groups were found to be neuropsychologically similar to one another and different from normal controls and patients with Alzheimer's disease. There were no significant differences among the schizophrenic groups in level or pattern of neuropsychological functioning. Patients with Alzheimer's disease demonstrated less efficient learning and particularly more rapid forgetting than did the other groups. CONCLUSIONS These findings suggest that neuropsychological impairment in schizophrenia is unrelated to current age, age at onset, or duration of illness. The study further suggests that the encephalopathy associated with schizophrenia is essentially nonprogressive and produces a pattern of deficits that is different from that seen in progressive cortical dementias.